Single molecule quantum-confined Stark effect measurements of semiconductor nanoparticles at room temperature

Park, Kyoung Won; Deutsch, Zvicka; Li, J. Jack; Oron, Dan; Weiss, Shimon

doi:10.1117/12.2001566

Cited by 32 publications

(65 citation statements)

References 37 publications

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“…The electro-optic property could be influenced by an applied electric field through the Stark effect [43]. The Pockels effect in semiconductor nanostructures may compete with the Stark effect in the sensitivity to an applied external electric field [44]. In spite of the attractive features of the quantum-confined Stark effect, which have been widely documented, it suffers from the drawbacks common to photon counting techniques, which cannot be applied to the vectorial determination of the electric field.…”

Section: Resultsmentioning

confidence: 99%

“…The strong second-order nonlinearity of the CdTe core with a large nonlinear coefficient d 14 of up to 200 pm∕V and CdS rods with a large nonlinear coefficient d 15 44, d 31 40, and d 33 77, 9 pm∕V [42], as well as their non-centrosymmetric crystalline structure, is suggestive of high electro-optic coefficients and correlatively of a strong Pockels effect. The coupling of a core/shell structure with a nanorod strongly increases the second-order nonlinearity of the hybrid system due to interference effects [11].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Full determination of single ferroelectric nanocrystal orientation by Pockels electro-optic microscopy

Trinh¹,

Mayer²,

Hajj³

et al. 2015

Appl. Opt.

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We present a nanoscale electro-optic imaging method allowing access to the phase response, which is not amenable to classical second-harmonic generation microscopy. This approach is used to infer the vectorial orientation of single domain ferroelectric nanocrystals, based on polarization-resolved Pockels microscopy. The electro-optic phase response of KTP nanoparticles yields the full orientation in the laboratory frame of randomly dispersed single nanoparticles, together with their electric polarization dipole. The complete vector determination of the dipole orientation is a prerequisite to important applications including ferroelectric nanodomain orientation, membrane potential imaging, and rotational dynamics of single biomolecules.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Full determination of single ferroelectric nanocrystal orientation by Pockels electro-optic microscopy

Trinh¹,

Mayer²,

Hajj³

et al. 2015

Appl. Opt.

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show abstract

“…For these experiments, non-ideal quasi type-II CdSe-CdS pcNRs (sample #3 in ref. 33) of dimensions 4 × 10 nm (diameter × length) were used (the synthesis of more suitable true type-II NRs with higher voltage sensitivity and proper dimensions is currently being pursued). pcNRs were applied directly to wild-type HEK293 cells cultured on a coverslip.…”

Section: Resultsmentioning

confidence: 99%

“…The signal quality could be greatly increased by a series of enhancements. For example, preliminary experiments and calculations suggest that seeded nanorods heterostructures with type-II band offset and large seed position asymmetry could exhibit very high voltage sensitivity 33 . Moreover, improved membrane insertion stability will reduce measurement noise and enhance the signal.…”

Section: Resultsmentioning

confidence: 99%

Membrane insertion of‐ and membrane potential sensing by semiconductor voltage nanosensors: feasibility demonstration

Park

Kuo

Shvadchak

et al. 2016

Preprint

Self Cite

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We develop membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. These voltage nanosensors are designed to self-insert into the cell membrane and optically record the membrane potential via the quantum confined Stark effect, with single-particle sensitivity. We present here the approach, design rules, and feasibility proves for this concept. With further improvements, semiconductor nanoparticles could potentially be used to study signals from many neurons in a large field-of-view over a long duration. Moreover, they could potentially report and resolve voltage signals on the nanoscale.peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/044057 doi: bioRxiv preprint first posted online Mar. 16, 2016; 2 Recent advances in inorganic colloidal synthesis methods have afforded the construction of functional semiconductor (SC) nanoparticles (NPs) with ever-increasing control over size, shape, composition, and sophisticated heterostructures that exhibit unique photophysical, chemical and electronic properties 1,2,3,4 . This precise command of nanoscale materials synthesis has allowed for the exquisite engineering of excited state wavefunctions 5,6,7 , charge confinement, spatiotemporal control of charge-separated states 8 , and manipulation of Fermi levels and redox potentials. As a result, SC NPs have proved to be very useful in numerous applications in optoelectronics 9,10 , biological imaging 11 , sensing 12,13,14 , catalysis 15 , and energy harvesting 16 .Integrating inorganic nanomaterials with naturally evolved or synthetically evolved biological machineries could yield highly sophisticated hybrid nanobiomaterials that outperform biological-only or inorganic-only materials. Such materials could be self-assembled by biomolecular recognition while maintaining the superior properties of inorganic materials 17,18 . Selfassembly of inorganic components by biomolecular recognition could align components in defined geometries, spatial orientations, and structures. In addition, careful design and control of the organic-inorganic interface could afford hybridization of electronic states, enhancement of radiationless energy transfer or electron transfer, or matching of Fermi levels with redox potentials.Numerous functionalization and bioconjugation methods have been developed for the integration of inorganic-biological hybrid nanomaterials that are water soluble and biologically active 19,20 . Such hybrid nanomaterials have been used for in vitro biosensing, intra-cellular biological imaging 21 , single protein tracking in live cells 19 , and in vivo molecular imaging with favorable in vivo biodistribution and targeting properties (including renal clearance) 11,22,23 .Much fewer attempts have been made to functionalize nanomaterials in a way that will allow their integration into the membrane. The ability to impart membrane protein-like properties peer-reviewed...

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“…7), including emission spectral broadening, red shifting and decreased intensity of emission peak. [74][75][76][77][78] Quantum dots have greater cross sections for one-and two-photo absorption than those of fluorescent proteins or voltage-sensitive dyes in which far larger cross sections are an important factor to facilitate voltage detection, suggesting quantum dots can be a new class for VSD development. Moreover, according to the signal detection theory, quantum dots can be used in reporting voltage dynamics with millisecond precision in neurophysiological conditions.…”

Section: Physico-chemical Basis Of Vsdmentioning

confidence: 99%

Recent Progress in Voltage-Sensitive Dye Imaging for Neuroscience

Tsytsarev

Liao

Kong

et al. 2014

j. nanosci. nanotech.

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Voltage-sensitive dye imaging (VSDi) enables visualization of information processing in different areas of the brain with reasonable spatial and temporal resolution. VSDi employs different chemical compounds to transduce neural activity directly into the changes in intrinsic optical signal. Physically, voltage-sensitive dyes (VSDs) are chemical probes that reside in the neural membrane and change their fluorescence or absorbance in response to membrane potential changes. Based on these features, VSDs can be divided into two groups-absorbance and fluorescence. The spatial and temporal resolution of the VSDi is limited mainly by the technical characteristics of the optical imaging setup (e.g., computer and light-sensitive device-charge-coupled device (CCD) camera or photodiode array). In this article, we briefly review the development of the VSD, technique of VSDi and applications in functional brain imaging.

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Single molecule quantum-confined Stark effect measurements of semiconductor nanoparticles at room temperature

Cited by 32 publications

References 37 publications

Full determination of single ferroelectric nanocrystal orientation by Pockels electro-optic microscopy

Full determination of single ferroelectric nanocrystal orientation by Pockels electro-optic microscopy

Membrane insertion of‐ and membrane potential sensing by semiconductor voltage nanosensors: feasibility demonstration

Recent Progress in Voltage-Sensitive Dye Imaging for Neuroscience

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