Single-molecule photosensitizers for NIR-II fluorescence and photoacoustic imaging guided precise anticancer phototherapy

Abstract

It is ideal yet challenging to achieve precise tumor targeting and high-quality imaging-guided combined photodynamic and photothermal therapy (PDT and PTT). In this study, we synthesized a series of D-π-A...

Suppressing ACQ of molecular photosensitizers by distorting the conjugated-plane for enhanced tumor photodynamic therapy

“…At the same time, cationic PSs can also target the suborganelles of cancer cells, which can promote a series of inflammatory and immune responses by the ROS produced during PDT, destroy the tumor microvasculature, and ultimately induce tumor cell death. 26–28…”

“…At the same time, cationic PSs can also target the suborganelles of cancer cells, which can promote a series of inammatory and immune responses by the ROS produced during PDT, destroy the tumor microvasculature, and ultimately induce tumor cell death. [26][27][28] However, cationic PSs can still be induced to aggregate by the physiological environment, biological polyanions (e.g., adenosine triphosphates (ATP) and pyrophosphate (PPi)), and high ionic strength, resulting in serious uorescence quenching which greatly limits the potential in vivo applications. 7,29,30 Therefore, it is very promising to develop cationic molecular PSs with excellent anti-ACQ properties in a physiological environment.…”

Cooperatively enhanced photothermal-chemotherapyviasimultaneously downregulating HSPs and promoting DNA alkylation in cancer cells

“…Photothermal therapy (PTT) is a precise, minimally invasive and low side-effect cancer treatment strategy, in which photosensitizers (PSs) convert light energy into heat through nonradiative transition to induce cancer cell necrosis. [1][2][3][4][5][6] As a heterogeneous group of molecular chaperones with various functions, heat shock proteins (HSPs) are regulated when cells are stressed in a variety of manners, especially by hyperthermia. [7][8][9][10] However, the upregulation of HSPs during PTT acts as a self-protective barrier to increase the heat resistance of cancer cells, which limits the treatment efficiency and fails to prevent tumor recurrence.…”

Plasmon enhanced catalysis-driven nanomotors with autonomous navigation for deep cancer imaging and enhanced radiotherapy

“…Photoacoustic imaging (PAI) has recently attracted considerable attention because it perfectly combines ultrasound imaging and optical imaging, with high contrast, deep tissue penetration, and sensitivity. [34][35][36][37][38][39] The optical absorber absorbs the laser pulse, and the energy is converted into heat, which induces thermal expansion; then, ultrasound waves are generated. It is well-established that gold nanorods (Au NRs) are a promising NIR-II PAI contrast agent due to their tunable aspect ratio, resulting in excellent optical absorption in the NIR-II region.…”