Single-molecule observations of human small heat shock proteins in complex with aggregation-prone client proteins
Lauren Rice,
Nicholas Marzano,
Dezerae Cox
et al.
Abstract:Small heat shock proteins (sHsps) are molecular chaperones that act to prevent the aberrant aggregation of misfolded proteins. Whilst it is widely suggested that sHsps prevent aggregation by binding to misfolded client proteins, the dynamic and heterogeneous nature of sHsps has hindered attempts to establish the mechanistic details of how sHsp-client protein complexes form. Single-molecule approaches have emerged as a powerful tool to investigate dynamic and heterogeneous interactions such as those that can oc… Show more
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