Abstract:ObjectiveStudy the dynamics of PTEN associated with laterally heterogeneous lipid bilayers using single molecule microscopy.BackgroundPhosphatase and tensin homologue deleted on chromosome 10 (PTEN), is one of the most frequent genes deleted/mutated in a wide variety of tumors. PTEN acts as an antagonist to PI 3‐kinase signaling, thereby affecting cellular processes such as cell proliferation and survival. PTEN activity is regulated by dynamic shuttling between the cytoplasm and the plasma membrane.MethodsWe u… Show more
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