Single-molecule conductance of DNA gated and ungated by DNA-binding molecules

Harashima, Takanori; Kojima, Chie; Fujii, Shintaro; Kiguchi, Manabu; Nishino, Tomoaki

doi:10.1039/c7cc02911j

Cited by 16 publications

(20 citation statements)

References 29 publications

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“…To this end, a technique based on scanning tunneling microscopy (STM) has been widely employed to investigate the electron transport in a single molecule . A variety of functional molecules such as diodes, switches, and transistors are being developed through such transport measurement. For example, it was found that conductance switching can be achieved by a photochromic reaction using diarylethene .…”

Section: Figurementioning

confidence: 99%

Highly Reproducible Formation of a Polymer Single‐Molecule Junction for a Well‐Defined Current Signal

et al. 2019

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Single‐molecule devices attract much interest in the development of nanoscale electronics. Although a variety of functional single molecules for single‐molecule electronics have been developed, there still remains the need to implement sophisticated functionalization toward practical applications. Given its superior functionality encountered in macroscopic materials, a polymer could be a useful building block in the single‐molecule devices. Therefore, a molecular junction composed of polymer has now been created. Furthermore, an automated algorithm was developed to quantitatively analyze the tunneling current through the junction. Quantitative analysis revealed that the polymer junction exhibits a higher formation probability and longer lifetime than its monomer counterpart. These results suggest that the polymer provides a unique opportunity to design both stable and highly functional molecular devices for nanoelectronics.

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Section: Figurementioning

confidence: 99%

Highly Reproducible Formation of a Polymer Single‐Molecule Junction for a Well‐Defined Current Signal

et al. 2019

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“…2015 年, Bruot 等 [51] [51] Figure 2 (a) A typical current-distance trace recorded in experiment. The plateau indicates a stable molecular junction was established between the tip and substrate; (b) Schematic of the modified STM-BJ setup with a modulating tip; (c) The evolution of amplitude of conductance modulation with time as the junction was mechanically modulated [51] 2017 年, Harashima 等 [52] 基于 STM-BJ 技术, 发现了通过调控碱基对之间的 π-π 堆积作用, 可以实现对 DNA 分子的电导调控. 如图 3a 所示, 研究者采用了溴化乙锭 (ethidium bromide, EB)和 Hoechst 33258 (HOE)两种染料分子.…”

Section: 扫描隧道显微镜裂结法mentioning

confidence: 99%

“…图 3 (a) EB 分子和 HOE 分子的结构式, 以及其与 DNA 分子结合位点的示意图; (b) 与 EB 分子发生结合后, 实验中测得的 DNA 分子的一维电导统计柱状图; (c) 与 HOE 分子发生结合后, 实验中测得的 DNA 分子的一维电导统计柱状图 [52] Figure 3 (a) Chemical structures of EB and HOE molecules, and the schematic illustration of the formation of EB-DNA complex and HOE-DNA complex; (b) 1D conductance histogram and typical traces for EB-DNA molecular junction; (c) 1D conductance histogram and typical traces for HOE-DNA molecular junction [52] 电化学方法具有调控分子能级的能力, 并且与其他调控方法相比, 电化学具有经济、方便、高效等优势. 一般情况下仅需要施加数百毫伏的电压, 即可以显著地改变反应的势垒、方向和产物.…”

Section: 扫描隧道显微镜裂结法unclassified

Advances in Charge Transport through DNA Molecular Junction by Employing Electrodes Pair with Nanometer-sized Separation

Yang¹,

Lei²,

Hong³

et al. 2019

Acta Chim. Sinica

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Molecular electronics is an interdisciplinary science that mainly studies the charge transport through molecules and its main goal is to fabricate molecular devices with electrical functionalities. In the state-of-art of molecular electronics, the research paradigm is to fabricate electrodes pair with nanometer-sized separation and construct the molecular junction through the assembly of target molecules with the electrodes pair. With this framework, the target molecule can be integrated to the macroscopic measurement circuit. DNA is one of the most significant biomolecules in natural sciences. It had drawn great attentions in biomedicine because of the carried genetic instructions. In molecular electronics, DNA also had attracted much interest due to the distinct structure and its capability of long-range charge transport. Nevertheless, in the early stage of molecular electronics, the probe molecules were limited to those with simple structures and short lengths. In recent years, molecular electronics had witnessed a rapid progress due to the developments in micro/nano-fabrication and the detection for weak current signal. Specifically, it includes the improvements in the success rate, efficiency, and stability of the fabricated molecular device. Benefiting from that, the probe molecules had been extended to a number of complex compounds like DNA. We give a brief introduction to the recent progress in the fabrication of DNA molecular junctions and the studies on the corresponding charge transport, most of which were made by using the research paradigm of fabricating electrodes pair with nanometer-sized separation. According to the fabrication methods that employed, these advances were introduced in two classes. One is that made by the as-called break junction methods, which include STM-break junction, conductive AFM and mechanically controllable break junction. The other is that made by the as-called cutting methods, which include cutting of carbon nanotube, graphene and silicon nanowire. We summarize the historical development of these methods and give a comparison between them. We also introduce some representative research on the charge transport through DNA molecular junction, and discuss the distinct features of DNA in electrical properties compared to the conventional small molecules. To conclude, we give a prospect on the future development of the studies on charge transport through DNA molecular junction.

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“…[1] To this end, at echnique based on scanning tunneling microscopy (STM) has been widely employed to investigate the electron transport in as ingle molecule. [2][3][4][5] Av ariety of functional molecules such as diodes, [6][7][8][9] switches, [10][11][12][13] and transistors [14][15][16][17] are being developed through such transport measurement. Fore xample,i tw as found that conductance switching can be achieved by ap hotochromic reaction using diarylethene.…”

mentioning

confidence: 99%

Highly Reproducible Formation of a Polymer Single‐Molecule Junction for a Well‐Defined Current Signal

et al. 2019

Self Cite

View full text Add to dashboard Cite

Single-molecule devices attract much interest in the development of nanoscale electronics.A lthough av ariety of functional single molecules for single-molecule electronics have been developed, there still remains the need to implement sophisticated functionalization towardp ractical applications. Given its superior functionality encountered in macroscopic materials,apolymer could be au seful building blocki nt he single-molecule devices.T herefore,amolecular junction composed of polymer has nowb een created. Furthermore,a n automated algorithm was developed to quantitatively analyze the tunneling current through the junction. Quantitative analysis revealed that the polymer junction exhibits ah igher formation probability and longer lifetime than its monomer counterpart. These results suggest that the polymer provides au nique opportunity to design both stable and highly functional molecular devices for nanoelectronics.

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Single-molecule conductance of DNA gated and ungated by DNA-binding molecules

Abstract: The single-molecule conductance of DNA was found to increase by over four fold upon intercalation, while the conductance nearly unaltered upon groove-binding. These effects are interpreted on the basis of the electronic interaction of the DNA-binding molecules with the stacked DNA bases.

Cited by 16 publications

References 29 publications

Highly Reproducible Formation of a Polymer Single‐Molecule Junction for a Well‐Defined Current Signal

Highly Reproducible Formation of a Polymer Single‐Molecule Junction for a Well‐Defined Current Signal

Advances in Charge Transport through DNA Molecular Junction by Employing Electrodes Pair with Nanometer-sized Separation

Highly Reproducible Formation of a Polymer Single‐Molecule Junction for a Well‐Defined Current Signal

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