Single-molecule chemiluminescent photosensitizer for a self-activating and tumor-selective photodynamic therapy of cancer

Silva, Luís Pinto da; Núñez-Montenegro, Ara; Magalhães, Carla M.; Ferreira, Paulo J.O.; Duarte, Diana; González-Berdullas, Patricia; Rodríguez‐Borges, José E.; Vale, Nuno; Silva, Joaquim C. G. Esteves da

doi:10.1016/j.ejmech.2019.111683

Cited by 27 publications

(75 citation statements)

References 49 publications

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“…Many other types of cancer have been the focus of PDT either as primary or complementary treatment, and the trend is similar in the majority of the new approaches. Gastric, colorectal, urogenital, bladder, and pancreatic cancer, besides previously discussed breast and lung cancers, are among the ones where PDT therapies have been deeply researched, either looking to improve the delivery of the known photosensitizers or oxygen, or improve the capability of the light source [ 155 , 156 , 157 , 158 , 159 , 160 , 161 ]. Nevertheless, the search for new photosensitizers is also an active target for the development of PDT.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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Due to their physical and chemical characteristics, anthocyanins are amongst the most versatile groups of natural compounds. Such unique signature makes these compounds a focus in several different areas of research. Anthocyanins have well been reported as bioactive compounds in a myriad of health disorders such as cardiovascular diseases, cancer, and obesity, among others, due to their anti-inflammatory, antioxidant, anti-diabetic, anti-bacterial, and anti-proliferative capacities. Such a vast number of action mechanisms may be also due to the number of structurally different anthocyanins plus their related derivatives. In this review, we highlight the recent advances on the potential use of anthocyanins in biological systems with particular focus on their photoprotective properties. Topics such as skin aging and eye degenerative diseases, highly influenced by light, and the action of anthocyanins against such damages will be discussed. Photodynamic Therapy and the potential role of anthocyanins as novel photosensitizers will be also a central theme of this review.

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Section: Photodynamic Therapymentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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“…C-TBD NPs could precisely monitor the tumor site via chemiluminescence imaging and efficiently inhibit tumor growth through PO-CL exciting TBD to produce

in the presence of H 2 O 2 , thus realizing simultaneous tumor diagnosis and treatment. Coelenterazine and its analogs can also act as a self-activating agent for PDT (Pinto da Silva et al, 2019 ; Sun et al, 2019 ). In the presence of a superoxide anion (overexpressed in tumor cells), coelenterazine can be oxidized into a dioxetanone intermediate, which then decomposing into CO 2 and the excited coelenteramide.…”

Section: Chemiluminescence-mediated Photodynamic Therapymentioning

confidence: 99%

“…The product will further undergo intersystem crossing to the triplet state, thus inducing the generation of

. This process can be enhanced by the introduction of a bromine heteroatom due to the heavy atom effect (Pinto da Silva et al, 2019 ).…”

Section: Chemiluminescence-mediated Photodynamic Therapymentioning

confidence: 99%

Photodynamic Therapy of Cancers With Internal Light Sources: Chemiluminescence, Bioluminescence, and Cerenkov Radiation

et al. 2020

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Photodynamic therapy (PDT) is a promising and minimally invasive modality for the treatment of cancers. The use of a self-illuminating system as a light source provides an intriguing solution to the light penetration issues of conventional PDT, which have gained considerable research interest in the past few years. This mini review aimed to present an overview of self-illuminating PDT systems by using internal light sources (chemiluminescence, bioluminescence, and Cerenkov radiation) and to give a brief discussion on the current challenges and future perspectives.

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“…Singlet oxygen ( 1 O 2 ) [16,17] is the most effective ROS in destroying cancer cells and is widely used in PDT [18,19]. Singlet oxygen can be detected using fluorescent probes [20,21], the most selective one being the Singlet Oxygen Sensor Green (SOSG) [22].…”

Section: Introductionmentioning

confidence: 99%

The effect of gold nanoparticle capping agents on 1O2 detection by singlet oxygen sensor green

Mitiche

Audibert

Marguet

et al. 2021

Journal of Photochemistry and Photobiology A: Chemistry

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Singlet Oxygen Sensor Green (SOSG) is the most widely used fluorescent probe for detecting singlet oxygen (1 O 2). 1 O 2 can be efficiently produced by exciting the surface plasmon of gold nanoparticles with laser pulses. However, gold nanoparticles are usually embedded in a chemical stabilizer that can interact with SOSG, leading to erroneous detection of 1 O 2. This article shows that the emission properties of SOSG strongly depend on the concentration of cetyltrimethylammonium bromide (CTAB), a capping agent widely used for nanoparticles synthesis and stabilization. The sensitivity of SOSG to 1 O 2 is also drastically affected by the presence of CTAB. This effect is due to the fluorescent probe's aggregation in CTAB premicellar aggregates and micelles, and the change in the probe configuration. Furthermore, the behavior of SOSG in the presence of two other widely-used surfactants, i.e., citrate and Polyethylene Glycol (PEG), is investigated to determine the right nanoparticle stabilizer to use with SOSG probe.

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Single-molecule chemiluminescent photosensitizer for a self-activating and tumor-selective photodynamic therapy of cancer

Cited by 27 publications

References 49 publications

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Photodynamic Therapy of Cancers With Internal Light Sources: Chemiluminescence, Bioluminescence, and Cerenkov Radiation

The effect of gold nanoparticle capping agents on 1O2 detection by singlet oxygen sensor green

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