Single mild traumatic brain injury results in transiently impaired spatial long-term memory and altered search strategies

Marschner, Linda; Schreurs, An; Lechat, Benoit; Mogensen, Jesper; Roebroek, Anton; Ahmed, Tariq; Balschun, Detlef

doi:10.1016/j.bbr.2018.02.040

Cited by 15 publications

(7 citation statements)

References 52 publications

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“…Given the prevalence of mTBI, it is imperative to understand the pathophysiological mechanisms of mTBI in the absence of objective findings. However, most animal models of mTBI involves injury that produce neurological deficits and/or morphological damage ( Chen et al, 2014 ; Lagraoui et al, 2012 ; Marschner et al, 2019 ; Taib et al, 2017 ; Xu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse

Cramer

Haley

Popa

et al. 2023

Neurobiology of Disease

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Section: Introductionmentioning

confidence: 99%

Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse

Cramer

Haley

Popa

et al. 2023

Neurobiology of Disease

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“…This complexity in the symptoms makes it difficult to diagnose and treat 24 . Many different rodent models of mTBIs have shown deficits in hippocampal based spatial and fear-based learning 14,15,[25][26][27][28][29][30] . However, these only represent a subset of the cognitive deficits associated with mTBIs.…”

Section: Introductionmentioning

confidence: 99%

Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice

Pinkowski

Guerin

Zhang

et al. 2020

Neurobiology of Learning and Memory

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“…Despite the growing body of work on experimental concussion, there is considerable heterogeneity in the literature. For instance, a number of studies have observed only transient deficits after mTBI ( Rostami et al, 2012 ; Marschner et al, 2018 ), or have required a large number of injuries ( Petraglia et al, 2014b ; Nolan et al, 2018 ). In addition, there is considerable variation even within similar models.…”

Section: Discussionmentioning

confidence: 99%

Repeat Closed-Head Injury in Male Rats Impairs Attention but Causes Heterogeneous Outcomes in Multiple Measures of Impulsivity and Glial Pathology

Haar

Wampler²,

Bhatia³

et al. 2022

Front. Behav. Neurosci.

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Repetitive mild traumatic brain injury, or concussion, can lead to the development of long-term psychiatric impairments. However, modeling these deficits is challenging in animal models and necessitates sophisticated behavioral approaches. The current set of studies were designed to evaluate whether a rubberized versus metal impact tip would cause functional deficits, the number of injuries required to generate such deficits, and whether different psychiatric domains would be affected. Across two studies, male rats were trained in either the 5-choice serial reaction time task (5CSRT; Experiment 1) to assess attention and motor impulsivity or concurrently on the 5CSRT and the delay discounting task (Experiment 2) to also assess choice impulsivity. After behavior was stable, brain injuries were delivered with the Closed-head Injury Model of Engineered Rotational Acceleration (CHIMERA) either once per week or twice per week (Experiment 1) or just once per week (Experiment 2). Astrocyte and microglia pathology was also assayed in relevant regions of interest. CHIMERA injury caused attentional deficits across both experiments, but only increased motor impulsivity in Experiment 1. Surprisingly, choice impulsivity was actually reduced on the Delay Discounting Task after repeat injuries. However, subsequent analyses suggested potential visual issues which could alter interpretation of these and attentional data. Subtle changes in glial pathology immediately after the injury (Experiment 1) were attenuated after 4 weeks recovery (Experiment 2). Given the heterogenous findings between experiments, additional research is needed to determine the root causes of psychiatric disturbances which may arise as a results of repeated brain injuries.

show abstract

Single mild traumatic brain injury results in transiently impaired spatial long-term memory and altered search strategies

Cited by 15 publications

References 52 publications

Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse

Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse

Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice

Repeat Closed-Head Injury in Male Rats Impairs Attention but Causes Heterogeneous Outcomes in Multiple Measures of Impulsivity and Glial Pathology

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