Single microbubble measurements of temperature dependent viscoelastic properties

Jordan, Sabina; Marchant, David; Todd, William M.; Mark, A

doi:10.1109/ultsym.2017.8092134

Cited by 2 publications

(2 citation statements)

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“…However, their MI values were measured close to the probe, whereas here (and in [18]) MI was measured at the depth of interest (30 mm here and 20mm in [18]). Finally, in vitro studies do not typically account for physiological temperatures [34]- [36] and pressures [37], gas exchange between blood and UCA [38], [39] or filtration by the lungs. We found that a maximum MI of 0.03 could be used without severe bubble destruction.…”

Section: ) Disruption Ratio (Dr)mentioning

confidence: 99%

High-Frame-Rate Contrast-Enhanced Ultrasound for Velocimetry in the Human Abdominal Aorta

Voorneveld

Engelhard

Vos

et al. 2018

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Treatment of abdominal aortic (AA) aneurysms and stenotic lesions may be improved by analyzing their associated blood flow patterns. Angle-independent blood flow patterns in the AA can be obtained by combining echo-particle image velocimetry (ePIV) with high frame rate contrast-enhanced ultrasonography. However, ePIV performance is affected by ultrasound contrast agent (UCA) concentration, microbubble stability and tissue clutter. In this study we assessed the influence of acoustic pressure and UCA concentration on image quality for ePIV analysis. We also compared amplitude modulation (AM) and singular value decomposition (SVD) as tissue suppression strategies for ePIV. Fourteen healthy volunteers were imaged in the region of the distal AA. We tested four different UCA bolus volumes (0.25, 0.5, 0.75 and 1.5 ml) and four different acoustic output pressures (mechanical indices: 0.01, 0.03, 0.06 and 0.09). As image quality metrics, we measured contrast-to-background ratio, bubble disruption ratio and maximum normalized cross-correlation value during ePIV. At mechanical indices ≥ 0.06, we detected severe bubble destruction, suggesting that very low acoustic pressures should be used for ePIV. SVD was able to suppress tissue clutter better than AM. The maximum tracking correlation was affected by both UCA concentration and flow rate, where at high flow rates, lower UCA concentrations resulted in slightly higher correlation values but more signal drop-outs during late diastole. High frame rate ePIV was successfully performed in the AA of healthy volunteers and shows promise for future studies in patients.

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Section: ) Disruption Ratio (Dr)mentioning

confidence: 99%

High-Frame-Rate Contrast-Enhanced Ultrasound for Velocimetry in the Human Abdominal Aorta

Voorneveld

Engelhard

Vos

et al. 2018

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

View full text Add to dashboard Cite

show abstract

“…However, their MI values were measured close to the probe, whereas here (and in [37]) MI was measured at the depth of interest (30 mm here and 20mm in [37]). Finally, in vitro studies do not typically account for physiological temperatures [168]- [170] and pressures [171] gas exchange between blood and UCA [172], [173] or filtration by the lungs. We found that a maximum MI of 0.03 could be used without severe bubble destruction.…”

Section: ) Disruption Ratio (Dr)mentioning

confidence: 99%

Blood flow quantification in the aortoiliac arteries : from bench to bedside

Engelhard¹

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The assessment of local blood flow patterns in patients with peripheral arterial disease is clinically relevant, since these patterns are related to atherosclerotic disease progression and loss of patency in stents placed in peripheral arteries, through mechanisms such as recirculating flow and low wall shear stress (WSS). However, imaging of vascular flow in these patients is technically challenging due to the often complex flow patterns that occur near atherosclerotic lesions. While several flow quantification techniques have been developed that could improve the outcomes of vascular interventions, accurate 2D or 3D blood flow quantification is not yet used in clinical practice. This article provides an overview of several important topics that concern the quantification of blood flow in patients with peripheral arterial disease. The hemodynamic mechanisms involved in the development of atherosclerosis and the current clinical practice in the diagnosis of this disease are discussed, showing the unmet need for improved and validated flow quantification techniques in daily clinical practice. This discussion is followed by a showcase of state-of-the-art blood flow quantification techniques and how these could be used before, during and after treatment of stenotic lesions to improve clinical outcomes. These techniques include novel ultrasound-based methods, Phase-Contrast Magnetic Resonance Imaging (PC-MRI) and Computational Fluid Dynamics (CFD). The last section discusses future perspectives, with advanced (hybrid) imaging techniques and artificial intelligence, including the implementation of these techniques in clinical practice.

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Single microbubble measurements of temperature dependent viscoelastic properties

Cited by 2 publications

References 0 publications

High-Frame-Rate Contrast-Enhanced Ultrasound for Velocimetry in the Human Abdominal Aorta

High-Frame-Rate Contrast-Enhanced Ultrasound for Velocimetry in the Human Abdominal Aorta

Blood flow quantification in the aortoiliac arteries : from bench to bedside

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