Single large study or meta-analysis parameters: choosing the most appropriate tool for Down syndrome screening in the first trimester

Ramos-Corpas, D.; Santiago, J.C.

doi:10.1002/pd.1568

Cited by 13 publications

(9 citation statements)

References 27 publications

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“…Potential publication bias was estimated using Egger's linear regression test with funnel plot [18]. Sensitivity analyses were assessed by deleting each study to reflect the influence of individual datasets on the pooled ORs [19]. Statistical analysis was performed using STATA version 11.0 (Stata Corporation, College Station, TX, USA) with two-sided P values.…”

Section: Methodsmentioning

confidence: 99%

Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk

Niu

Yuan

Zhou

2014

Mediators of Inflammation

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Epidemiological studies have suggested that interleukin-17 (IL-17) polymorphisms are associated with cancer risk. However, the results of these studies are inconsistent. Therefore, we performed a meta-analysis to obtain a precise conclusion. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association of the IL-17A rs2275913G>A and IL-17F rs763780T>C polymorphisms with cancer risk. Publication bias and sensitivity analyses were performed to ensure the statistical power. Overall, 10 relevant case-control studies involving 4,516 cases and 5,645 controls were included. The pooled ORs with 95% CIs indicated that the IL-17A rs2275913G>A polymorphism was significantly associated with increased cancer risk (for A versus G: OR = 1.28, 95% CI: 1.16–1.41, P < 0.001, I 2 = 61.1%; for GA versus GG: OR = 1.12, 95% CI: 1.02–1.23, P = 0.015, I 2 = 27.8%; for AA versus GG: OR = 1.71, 95% CI: 1.38–2.41, P < 0.001, I 2 = 69.6%; for GA + AA versus GG: OR = 1.23, 95% CI: 1.13–1.34, P < 0.001, I 2 = 6.4%; for AA versus GG + GA: OR = 1.62, 95% CI: 1.27–2.07, P < 0.001, I 2 = 81.4%). Succeeding analysis of HWE and stratified analysis of gastric cancer and the Asian (and Chinese) population revealed similar results. The IL-17F rs763780T>C polymorphism was also significantly associated with gastric cancer development. Overall, the present meta-analysis suggests that IL-17 polymorphisms increase the risk of developing cancer, particularly gastric cancer, in the Asian (and Chinese) population.

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Section: Methodsmentioning

confidence: 99%

Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk

Niu

Yuan

Zhou

2014

Mediators of Inflammation

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“…Sensitivity analysis was conducted by elimination of a single research involved in the meta-analysis each time. 37 If there were 10 or more studies, publication bias was evaluated by Begg's test and Egger's linear regression. When publication bias was found, Duval and Tweedie's 38 trim and fill procedure was performed.…”

Section: Analysis Of Variablesmentioning

confidence: 99%

Cranial base characteristics in anteroposterior malocclusions: A meta-analysis

Gong

Wang

et al. 2015

The Angle Orthodontist

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“…Otherwise, the random-effects model (the DerSimonian and Laird method) was applied. The stability of the meta-analysis' results was accessed by performing one-way sensitivity analyses (Ramos-Corpas and Santiago, 2006), and publication bias was evaluated with Egger's linear regression test by visual inspection of the funnel plot (Egger et al, 1997).…”

Section: Statistical Analysesmentioning

confidence: 99%