Single intravenous and oral dose pharmacokinetics of florfenicol in the channel catfish (Ictalurus punctatus)

Abstract

Plasma distribution and elimination of florfenicol in channel catfish were investigated after a single dose (10 mg/kg) of intravenous (i.v.) or oral administration in freshwater at a mean water temperature of 25.4 °C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After i.v. florfenicol injection, the terminal half-life (t(1/2)), volume of distribution at steady state (V(ss)), and central volume of distribution (V(c)) were 8.25 h, 0.9 and 0.381 L/kg, respectively. After oral administration of florfenicol, the terminal t(1/2), C(max), T(max), and oral bioavailability (F) were 9.11 h, 7.6 μg/mL, 9.2 h, and 1.09, respectively. There was a lag absorption time of 1.67 h in oral dosing. Results from these studies support that 10 mg florfenicol/kg body weight in channel catfish is an efficacious dosage following oral administration.

Pharmacokinetics of Florfenicol after Oral Administration in Yellow Catfish, Pelteobagrus fulvidraco

“…In this study, the t 1/2 β in plasma of yellow catfish was 9.63 h with a Cl of 0.18 L/h/kg, which is consistent with the results found in tilapia (10.03 h, Feng and Jia ) and channel catfish (9.11 h, Gaunt et al ). The order of t 1/2 β in different tissues in this study were the following: kidney (15.75 h) = muscle (15.75 h) > skin (14.44 h) > liver (11.55 h) > plasma (9.63 h).…”

“…administration at a dose of 10 mg/kg at 25 C. The mean values of C max and T max in the plasma of yellow catfish were 2.35 µg/mL and 7.25 h, respectively, which were lower and earlier than those in cod (12.40 µg/mL and 9 h after 10 mg/kg of oral doses, Samuelsen et al ), Korean catfish (9.59 µg/mL and 8 h after 10 mg/kg of oral doses, Park et al ), tilapia (4.46 µg/mL and 12 h after 10 mg/kg of oral doses, Feng et al ), and channel catfish, I . punctatus (7.61 ± 0.87 µg/mL and 9.20 ± 2.53 h after after 10 mg/kg of oral doses, Gaunt et al ). The order of the C max values in yellow catfish was the following: kidney > liver > muscle > skin > plasma.…”

“…Pharmacokinetic profiles of FF have been described in Atlantic salmon, Salmo salar (Martinsen et al ; Horsberg et al ); Korean catfish, Silurus asotus (Park et al ); koi carp, Cyprinus carpio (Yanong et al ); cod, Gadus morhua (Samuelsen et al ); red pacu, Piaractus brachypomus (Lewbart et al ); tilapia, Oreochromis spp (Feng and Jia ; Gaikowski et al ); crucian carp, Carassius auratus cuvieri (Sun et al ); olive flounder, Paralichthys olivaceus (Lim et al ); and channel catfish, Ictalurus punctatus (Gaunt et al ). Yellow catfish, Pelteobagrus fulvidraco , is an important commercial fish and is widely cultured in Southeast Asian countries, especially China.…”

Provisional epidemiological cutoff values for standard broth microdilution susceptibility testing of Flavobacterium columnare

“…However, ECVs do define the MIC distribution of WT isolates that are integral, along with pharmacokinetic/pharmacodynamic data and clinical outcome data, to set clinical breakpoints (CLSI 2008(CLSI , 2011. Therefore, our results, in combination with existing pharmacokinetic data (Gaunt et al 2012(Gaunt et al , 2013, data on pharmacodynamics and data on treatment outcomes, could help foster clinical breakpoints for F. columnare.…”

“…Therefore, our results, in combination with existing pharmacokinetic data (Gaunt et al . , ), data on pharmacodynamics and data on treatment outcomes, could help foster clinical breakpoints for F. columnare .…”