Single Interdigital Transducer Approach for Gravimetrical SAW Sensor Applications in Liquid Environments

Nguyen, Vu Hoa; Kaulen, Corinna; Simon, Ulrich; Schnakenberg, Uwe

doi:10.3390/s17122931

Cited by 11 publications

(6 citation statements)

References 51 publications

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“…Finally, the ATs platform can be made of a single, integrated micro-device, avoiding any moving parts and/or complicated setup procedures, which make the system very easy to use ( Guo et al, 2016 ). In this regard, the implementation of surface acoustic wave (SAW) transducers ( Ahmed et al, 2016 ) for on-chip manipulation of cells has been reported ( Voiculescu and Nordin, 2012 ; Ding et al, 2014 ; Nguyen et al, 2017 ).…”

Section: Tweezing Methodsmentioning

confidence: 99%

Biomechanical Characterization at the Cell Scale: Present and Prospects

et al. 2018

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The rapidly growing field of mechanobiology demands for robust and reproducible characterization of cell mechanical properties. Recent achievements in understanding the mechanical regulation of cell fate largely rely on technological platforms capable of probing the mechanical response of living cells and their physico–chemical interaction with the microenvironment. Besides the established family of atomic force microscopy (AFM) based methods, other approaches include optical, magnetic, and acoustic tweezers, as well as sensing substrates that take advantage of biomaterials chemistry and microfabrication techniques. In this review, we introduce the available methods with an emphasis on the most recent advances, and we discuss the challenges associated with their implementation.

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Section: Tweezing Methodsmentioning

confidence: 99%

Biomechanical Characterization at the Cell Scale: Present and Prospects

et al. 2018

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“…, k n are regression coefficients, and e is error. Based on the simulation output data, the regression coefficients in equation (10) are solved by the least square method.…”

Section: Effect Of Idt Position Parameters On Sensor Sensitivitymentioning

confidence: 99%

“…[1][2][3][4] Because SAW sensors are particularly sensitive to the environmental changes on the substrate surface, they are widely used in the detection of physical, 5 chemical, 6 and biological 7 data. With the continuous increase in SAW sensor applications, the study of the aspects of theoretical enrichment, 8,9 working mechanism innovation, 10 simulation model improvement, 11 and working performance development 12 for SAW sensors has become a hot research topic.…”

Section: Introductionmentioning

confidence: 99%

Effect of IDT position parameters on SAW yarn tension sensor sensitivity

Lei

Mian

et al. 2020

Measurement and Control

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In this paper, the effect of the interdigital transducer (IDT) position parameters on the surface acoustic wave (SAW) yarn tension sensor sensitivity is investigated. The stress–strain characteristic of substrate was studied by the combination of finite element simulation and regression analysis method. According to this characteristic, the function relationship between the SAW yarn tension sensor sensitivity and the IDT position parameters was built using the regression analysis method. The monotonicity of the regression function was also given. On this basis, a novel sensitivity optimal scheme was proposed and solved by the quadratic programming method. Its solution demonstrates that the optimum sensitivity can be obtained when the IDT is 8.9 mm to the left side of the substrate and the IDT is 0.3 mm to the top edge of the substrate within a domain of the IDT position parameters. The SAW yarn tension sensor with corresponding IDT position parameters was fabricated to validate the correctness of the sensitivity optimal scheme. The measured results indicate that the SAW yarn tension sensor sensitivity can reach 813.69 Hz/g, which confirms that the novel scheme is effective.

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“…To form SAM using the aliphatic thiols to modify the gold electrode surface in the biosensor design are often observed in the literature [19][20][21][22][23]. Whereas, it is seen that the use of aromatic thiols is much less in biosensor studies [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

A new electrochemical impedance biosensor based on aromatic thiol for alpha-1 antitrypsin determination

Yağar¹,

Özcan²,

Mehmet³

2021

Turk J Chem

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Alpha-1 Antitrypsin (A1AT) is one of the acute phase proteins, which synthesized in liver. A1AT helps inhibiting the activity of many proteases, but its main task is to protect the lungs from the attack of neutrophil elastase. In an autosomal hereditary disease known as alpha-1 antitrypsin deficiency, the A1AT amount in blood serum decreases and so the risk of developing emphysema, liver apoptosis and liver cancer increase. Thus, the detection of A1AT concentration in blood serum is very important. In this study, an impedimetric biosensor was developed forming SAM (selfassembled monolayer) with 4-mercaptophenylacetic acid (4MPA) on the surface of the gold electrode. A1AT biosensor was constructed using immobilization of A1AT specific antibody (Anti-A1AT) after activating the carboxyl groups of 4MPA by EDC/NHS. Each immobilization stage was characterized by using electrochemical 2 impedance spectroscopy, cyclic voltammetry and scanning electron microscopy with energy dispersive x-ray spectroscopy. With the designed biosensor, precise and highly reproducible results were obtained for A1AT concentration in the range of 100-600 µg/mL. Also, the A1AT detection was successfully carried out in artificial serum solutions spiked with A1AT.

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Single Interdigital Transducer Approach for Gravimetrical SAW Sensor Applications in Liquid Environments

Cited by 11 publications

References 51 publications

Biomechanical Characterization at the Cell Scale: Present and Prospects

Biomechanical Characterization at the Cell Scale: Present and Prospects

Effect of IDT position parameters on SAW yarn tension sensor sensitivity

A new electrochemical impedance biosensor based on aromatic thiol for alpha-1 antitrypsin determination

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