Single Injection Thermodilution

Jansen, Jos R. C.; Schreuder, Jan J.; Settels, Jos J.; Kornet, Lilian; Penn, Olaf C.; Mulder, Paul; Versprille, A.; Wesseling, Karel H.

doi:10.1097/00000542-199609000-00006

Cited by 25 publications

(11 citation statements)

References 28 publications

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“…Investigators have previously explored methods of minimizing the errors in the intermittent thermodilution technique [8–12]. The best method is to average the results of three or four thermodilution measurements with the injection of cold fluid equidistantly distributed over the ventilatory cycle.…”

Section: Indicator Dilution Techniquesmentioning

confidence: 99%

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Methods in pharmacology: measurement of cardiac output

Geerts¹,

Aarts²,

Jansen

2011

Brit J Clinical Pharma

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Many methods of cardiac output measurement have been developed, but the number of methods useful for human pharmacological studies is limited. The ‘holy grail’ for the measurement of cardiac output would be a method that is accurate, precise, operator independent, fast responding, non‐invasive, continuous, easy to use, cheap and safe. This method does not exist today. In this review on cardiac output methods used in pharmacology, the Fick principle, indicator dilution techniques, arterial pulse contour analysis, ultrasound and bio‐impedance are reviewed.

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Section: Indicator Dilution Techniquesmentioning

confidence: 99%

“…technique [8][9][10][11][12].The best method is to average the results of three or four thermodilution measurements with the injection of cold fluid equidistantly distributed over the ventilatory cycle. For such an approach injections of fluid must be done with an injector under computer control.…”

Section: Figurementioning

confidence: 99%

Methods in pharmacology: measurement of cardiac output

Geerts¹,

Aarts²,

Jansen

2011

Brit J Clinical Pharma

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“…If any variable differed by more than 10 % from the mean of the series, the series was rejected [23]. To obtain unbiased averages of the thermodilutiondetermined cardiac output, injections must be executed at random phases of the respiratory cycle.…”

Section: Data Acquisition and Analysismentioning

confidence: 99%

Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress

et al. 1999

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The relationship between aortic flow and pressure is described by a three-element model of the arterial input impedance, including continuous correction for variations in the diameter and the compliance of the aorta (Modelflow). We computed the aortic flow from arterial pressure by this model, and evaluated whether, under orthostatic stress, flow may be derived from both an invasive and a non-invasive determination of arterial pressure. In 10 young adults, Modelflow stroke volume (MFSV) was computed from both intra-brachial arterial pressure (IAP) and non-invasive finger pressure (FINAP) measurements. For comparison, a computer-controlled series of four thermodilution estimates (thermodilution-determined stroke volume; TDSV) were averaged for the following positions: supine, standing, head-down tilt at 20 degrees (HDT20) and head-up tilt at 30 degrees and 70 degrees (HUT30 and HUT70 respectively). Data from one subject were discarded due to malfunctioning thermodilution injections. A total of 155 recordings from 160 series were available for comparison. The supine TDSV of 113+/-13 ml (mean+/-S.D.) dropped by 40% to 68+/-14 ml during standing, by 24% to 86+/-12 ml during HUT30, and by 51% to 55+/-15 ml during HUT70. During HDT20, TDSV was 114+/-13 ml. MFSV for IAP underestimated TDSV during HDT20 (-6+/-6 ml; P<0.05), but that for FINAP did not (-4+/-7 ml; not significant). For HUT70 and standing, MFSV for IAP overestimated TDSV by 11+/-10 ml (HUT70; P<0.01) and 12+/-9 ml (standing; P<0.01). However, the offset of MFSV for FINAP was not significant for either HUT70 (3+/-8 ml) or standing (3+/-9 ml). In conclusion, due to orthostasis, changes in the aortic transmural pressure may lead to an offset in MFSV from IAP. However, Modelflow correctly calculated aortic flow from non-invasively determined finger pressure during orthostasis.

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“…Another disadvantage of ATD is the higher sensitivity to baseline alteration, which can be reduced by increasing the amount of injected indicator. Interestingly, in our septic shock model, COpc was revealed to be satisfactorily accurate up to 5 h. We revealed a bias of about 12% at 5 h. Given the 15% variability in the pulmonary artery thermodilution derived CO measurement the agreement between COpcCAL and COpcNoCAL is reliable (15). COpcNoCAL remained unchanged over 9 h in the control animals whereas COpcNoCAL increased in septic animals.…”

Section: Discussionmentioning

confidence: 65%

Reliability of continuous cardiac output determination by pulse‐contour analysis in porcine septic shock

Schürholz

Meyer

Friedrich

et al. 2006

Acta Anaesthesiol Scand

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Background: Pulse-contour analysis represents a technique for cardiac output (CO)-measurement and allows continuously monitoring trends in CO. We evaluated reliability of pulse-contour CO (COpc) in septic shock. Methods: Seventeen anaesthetized and mechanically ventilated pigs were investigated. After baseline measurements, 14 animals received 0.75 g/kg body weight faeces into the abdominal cavity to induce sepsis and were observed over 9 h, three animals served as controls. A central venous catheter was inserted into the jugular vein and an arterial catheter for thermodilution was inserted into the femoral artery. Two bedside computers were used for COpc. After induction of sepsis, COpc-computer No. 1 (COpcCAL) was recalibrated hourly. No further calibrations were performed in computer No. 2 (COpcNoCAL). We directly compared COpcCAL hourly before recalibration with COpcNoCAL. One hundred and seventy parallel triplicate determinations of CO were analysed using the method of Bland-Altman. Results: Three hours after sepsis induction, correlation between recalibrated and non-recalibrated CO was r ¼ 0.74, P < 0.01, at

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Single Injection Thermodilution

Cited by 25 publications

References 28 publications

Methods in pharmacology: measurement of cardiac output

Methods in pharmacology: measurement of cardiac output

Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress

Reliability of continuous cardiac output determination by pulse‐contour analysis in porcine septic shock

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