Single fiber mapping of spatial excitation patterns in the electrically stimulated auditory nerve

Honert, Chris van den; Stypulkowski, Paul H.

doi:10.1016/0378-5955(87)90167-5

Cited by 192 publications

(79 citation statements)

References 14 publications

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“…Radially oriented electrode pairs produced more restricted ICC activation patterns (and by inference more restricted activation of the auditory nerve array) than did longitudinal pairs. This conclusion is consistent with the results of studies of the influence of electrode orientation on physiological activation selectivity in the auditory nerve of hearing cats (Van den Honert and Stypulkowski 1987). This study reported that radial bipolar electrodes activated the auditory nerve highly selectively, whereas longitudinal bipolar electrodes produced much broader activation.…”

Section: Discussionsupporting

confidence: 92%

“…Studies of the spread of auditory nerve activation in response to electric stimuli have involved clinical and psychophysical studies in humans (Tong and Clark 1986;Lim et al 1989;Chatterjee and Shannon 1998;Hanekom and Shannon 1997), electrophysiological studies in animals (Woolsey and Walzl 1943; Van den Honert and Stypulkowski 1987;Snyder et al 1990Snyder et al , 1991Leake et al 1991Leake et al , 1995Leake et al , 2000Kral et al 1998;Shepherd et al 1999;Rebscher et al 2001;Taniguchi et al 1997;Raggio and Schreiner. 1999;Bierer and Middlebrooks 2002;Middlebrooks and Bierer 2002), and theoretical modeling studies (Finley 1989;Finley et al 1987Finley et al , 1990Frijns et al 1994Frijns et al , 1995Frijns et al , 1996Rattay et al 2001a,b).…”

Section: Introductionmentioning

confidence: 99%

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Topographic Spread of Inferior Colliculus Activation in Response to Acoustic and Intracochlear Electric Stimulation

Snyder

Bierer

Middlebrooks

2004

JARO

138

158

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The design of contemporary multichannel cochlear implants is predicated on the presumption that they activate multiple independent sectors of the auditory nerve array. The independence of these channels, however, is limited by the spread of activation from each intracochlear electrode across the auditory nerve array. In this study, we evaluated factors that influence intracochlear spread of activation using two types of intracochlear electrodes: (1) a clinical-type device consisting of a linear series of ring contacts positioned along a silicon elastomer carrier, and (2) a pair of visually placed (VP) ball electrodes that could be positioned independently relative to particular intracochlear structures, e.g., the spiral ganglion. Activation spread was estimated by recording multineuronal evoked activity along the cochleotopic axis of the central nucleus of the inferior colliculus (ICC). This activity was recorded using silicon-based singleshank, 16-site recording probes, which were fixed within the ICC at a depth defined by responses to acoustic tones. After deafening, electric stimuli consisting of single biphasic electric pulses were presented with each electrode type in various stimulation configurations (monopolar, bipolar, tripolar) and/or various electrode orientations (radial, off-radial, longitudinal). The results indicate that monopolar (MP) stimulation with either electrode type produced widepread excitation across the ICC. Bipolar (BP) stimulation with banded pairs of electrodes oriented longitudinally produced activation that was somewhat less broad than MP stimulation, and tripolar (TP) stimulation produced activation that was more restricted than MP or BP stimulation. Bipolar stimulation with radially oriented pairs of VP ball electrodes produced the most restricted activation. The activity patterns evoked by radial VP balls were comparable to those produced by pure tones in normal-hearing animals. Variations in distance between radially oriented VP balls had little effect on activation spread, although increases in interelectrode spacing tended to reduce thresholds. Bipolar stimulation with longitudinally oriented VP electrodes produced broad activation that tended to broaden as the separation between electrodes increased.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Topographic Spread of Inferior Colliculus Activation in Response to Acoustic and Intracochlear Electric Stimulation

Snyder

Bierer

Middlebrooks

2004

JARO

138

158

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“…Overall, the feline functions suggest a general trend for greater spike-rate limitation for higher threshold ANFs, a trend consistent threshold-related adaptation reported by Zhang et al (2007). The broad distribution of ANF rate-level functions is consistent with estimated 12-20 dB ranges of ANF thresholds within the feline auditory nerve (van den Honert and Stypulkowski 1987a;Miller et al 1999b). …”

Section: Relationship Between Ecap Thresholds and Dynamic Ranges Of Anfssupporting

confidence: 79%

“…This study focused on analyses of three measures of ANF responses (spike rate, VS, and F 0 amplitude) and how they varied as functions of time (using the 50 ms epochs) and changes in stimulus level. As noted before, initial spike rate was chosen as a means of assessing stimulus-level effects across a group of ANFs, as fibers will exhibit a range of electric thresholds, presumably due to the across-nerve gradient in stimulus strength and ANF fiber diameter (van den Honert and Stypulkowski 1987a;Miller et al 1999b). Pulse trains were presented repeatedly (typically 30 times) to obtain ANF firing statistics, with a 900-ms silent period between trains.…”

Section: Stimulus Presentationmentioning

confidence: 99%

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Miller

Abbas

et al. 2010

JARO

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Response rates of auditory nerve fibers (ANFs) to electric pulse trains change over time, reflecting substantial spike-rate adaptation that depends on stimulus parameters. We hypothesize that adaptation affects the representation of amplitude-modulated pulse trains used by cochlear prostheses to transmit speech information to the auditory system. We recorded cat ANF responses to sinusoidally amplitude-modulated (SAM) trains with 5,000 pulse/s carriers. Stimuli delivered by a monopolar intracochlear electrode had fixed modulation frequency (100 Hz) and depth (10%). ANF responses were assessed by spike-rate measures, while representation of modulation was evaluated by vector strength (VS) and the fundamental component of the fast Fourier transform (F 0 amplitude). These measures were assessed across the 400 ms duration of pulse-train stimuli, a duration relevant to speech stimuli. Different stimulus levels were explored and responses were categorized into four spike-rate groups to assess level effects across ANFs. The temporal pattern of rate adaptation to modulated trains was similar to that of unmodulated trains, but with less rate adaptation. VS to the modulator increased over time and tended to saturate at lower spike rates, while F 0 amplitude typically decreased over time for low driven rates and increased for higher driven rates. VS at moderate and high spike rates and degree of F 0 amplitude temporal changes at low and moderate spike rates were positively correlated with the degree of rate adaptation. Thus, high-rate carriers will modify the ANF representation of the modulator over time. As the VS and F 0 measures were sensitive to adaptation-related changes over different spike-rate ranges, there is value in assessing both measures.

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“…Comparisons of neuronal responses to monopolar electrical stimulation and bipolar electrical stimulation (one intracochlear stimulating contact and a second intracochlear return contact) have shown mixed results. The majority of studies have shown more broadly distributed neuronal activation for monopolar than for bipolar intracochlear stimulation, including studies in the auditory nerve (van den Honert and Stypulkowski 1987;Kral et al 1998), inferior colliculus (Merzenich and White 1977;Snyder et al 1990Snyder et al , 2004Snyder et al , 2008Middlebrooks and Snyder 2007), and auditory cortex (Bierer and Middlebrooks 2002); but a few studies have shown similar neuronal activation patterns for monopolar and bipolar stimulation at low to moderate stimulus intensities (Liang et al 1999;Rebscher et al 2001;Smith and Delgutte 2007).…”

Section: Introductionmentioning

confidence: 99%

Monopolar Intracochlear Pulse Trains Selectively Activate the Inferior Colliculus

Schoenecker

Bonham

Stakhovskaya

et al. 2012

JARO

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Previous cochlear implant studies using isolated electrical stimulus pulses in animal models have reported that intracochlear monopolar stimulus configurations elicit broad extents of neuronal activation within the central auditory system-much broader than the activation patterns produced by bipolar electrode pairs or acoustic tones. However, psychophysical and speech reception studies that use sustained pulse trains do not show clear performance differences for monopolar versus bipolar configurations. To test whether monopolar intracochlear stimulation can produce selective activation of the inferior colliculus, we measured activation widths along the tonotopic axis of the inferior colliculus for acoustic tones and 1,000-pulse/s electrical pulse trains in guinea pigs and cats. Electrical pulse trains were presented using an array of 6-12 stimulating electrodes distributed longitudinally on a space-filling silicone carrier positioned in the scala tympani of the cochlea. We found that for monopolar, bipolar, and acoustic stimuli, activation widths were significantly narrower for sustained responses than for the transient response to the stimulus onset. Furthermore, monopolar and bipolar stimuli elicited similar activation widths when compared at stimulus levels that produced similar peak spike rates. Surprisingly, we found that in guinea pigs, monopolar and bipolar stimuli produced narrower sustained activation than 60 dB sound pressure level acoustic tones when compared at stimulus levels that produced similar peak spike rates. Therefore, we conclude that intracochlear electrical stimulation using monopolar pulse trains can produce activation patterns that are at least as selective as bipolar or acoustic stimulation.

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Single fiber mapping of spatial excitation patterns in the electrically stimulated auditory nerve

Cited by 192 publications

References 14 publications

Topographic Spread of Inferior Colliculus Activation in Response to Acoustic and Intracochlear Electric Stimulation

Topographic Spread of Inferior Colliculus Activation in Response to Acoustic and Intracochlear Electric Stimulation

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Monopolar Intracochlear Pulse Trains Selectively Activate the Inferior Colliculus

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