Single-exhalation method for study of lobar and segmental lung function by mass spectrometry in man

Denison, D M; Davies, N.J.H.; Meyer, Michaël; Pierce, Robert J; Scheid, P.

doi:10.1016/0034-5687(80)90106-1

Cited by 28 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When this had been accomplished, the endoscope and the thermocouple within were secured to prevent movement. (The technique used represents a modification of that used at the Lung Function Unit of the Brompton Hospital for the measurement of segmental gas exchange [13], and permitted us to monitor the position of the probe.) The 95% response time of the thermocouple was 0.19 s and was judged adequate for the pur-poses of this study.…”

Section: Methodsmentioning

confidence: 99%

Direct recordings of the temperatures in the tracheobronchial tree in normal man.

McFadden¹,

Denison²,

Waller³

et al. 1982

J. Clin. Invest.

113

View full text Add to dashboard Cite

A B S T R A C T In an effort to determine how far inspired air could penetrate into the respiratory tract before being brought to body conditions, we measured the temperature in the airways of the anterior basilar segment of the right lower lobe in five normal subjects while they breathed air at subfreezing and ambient conditions. During quiet breathing, most of the heating of the incoming gas took place in the upper airways as expected. However, as the thermal burden was increased by rapid inspirations, frigid air, and hyperventilation, the temperature of the distal airways progressively fell and the point at which the incoming air reached body conditions moved deep into the periphery of the lung. These findings demonstrate that heat and water transfer is not localized to one region, but rather is a continuous process that begins the moment the air enters the body and involves as much of the respiratory tract as necessary to complete the task.

show abstract

Section: Methodsmentioning

confidence: 99%

Direct recordings of the temperatures in the tracheobronchial tree in normal man.

McFadden¹,

Denison²,

Waller³

et al. 1982

J. Clin. Invest.

113

View full text Add to dashboard Cite

show abstract

“…With a single inspiration of carbon monoxide the diffusing capacity of small units of the lung can be measured (Denison et al, 1980). Several inert tracer gases have been used to assess different aspects of lung function (Williams et al, 1979).…”

Section: Regional Lungfunctionmentioning

confidence: 99%

Current status of fibreoptic bronchoscopy

Dhillon¹,

Collins²

1984

Postgraduate Medical Journal

View full text Add to dashboard Cite

“…In t959, Cander and Forster described a modification of this method employing a series of breath holding maneuvers to quantify the rate of disappearance of a soluble inert gas in relation to an insoluble inert gas [2]. In the 80 years since the original technical description, scattered reports have appeared describing the application of this technique [3,4,5,6,7] and establishing its validity in various groups of subjects [8,9,10]. Although most reports have generally followed the analytic approach outlined by Cander and Forster, different authors have utilized minor modifications of this approach and no methodology has been accepted as a standard.…”

Section: Introductionmentioning

confidence: 98%

“…Although most reports have generally followed the analytic approach outlined by Cander and Forster, different authors have utilized minor modifications of this approach and no methodology has been accepted as a standard. The use of this technique has been hindered by cumbersome analysis methods that require visual determination of expired gas concentration plateaus from hard copy multichannel plots and manual digitalization for entry into a main frame computer for analysis [8,9,3,10]. Some investigators have relied on complex instrumentation beyond the capabilities of most pulmonary function laboratories and difficult to apply in a routine clinical setting [7].…”

Section: Introductionmentioning

confidence: 99%

Clinical non-invasive measurement of effective pulmonary capillary blood flow

Winter

1995

J Clin Monitor Comput

View full text Add to dashboard Cite

Since traditional pulmonary function testing is centered on measurements of air flow and lung volume, a method to assess the pulmonary circulation might improve our ability to evaluate diseases that impact upon pulmonary hemodynamics. We have developed a PC based application that rapidly calculates pulmonary blood flow. Subjects rebreath a mixture of 10% argon and 3.5% freon for 20 seconds. Gas concentrations at the mouth are monitored by a clinical mass spectrometer and signals are acquired and processed with off-the-shelf hardware. To test the accuracy and reproducibility of this technique, patients with pulmonary artery catheters were assessed by standard thermodilution methods and the rebreathing test. Measurements using this non-invasive technology closely corelate with invasive thermodilution methods (r = 0.980) and show equivalent reproducibility (average standard error = 2.5%). This application of signal processing technology can extend the role of pulmonary function testing to include routine evaluation of the pulmonary circulation.

show abstract

Single-exhalation method for study of lobar and segmental lung function by mass spectrometry in man

Cited by 28 publications

References 13 publications

Direct recordings of the temperatures in the tracheobronchial tree in normal man.

Direct recordings of the temperatures in the tracheobronchial tree in normal man.

Current status of fibreoptic bronchoscopy

Clinical non-invasive measurement of effective pulmonary capillary blood flow

Contact Info

Product

Resources

About