Objective The present study investigated the cost per delivery for all public reimbursed ART cycles performed in Lombardy. MethodsAnalysis of costs for the 2017 and 2018 Delivery and Cumulative Delivery Rates extracted from the ART Italian Registry on oocytes retrieval, fresh and frozen embryos and oocytes performed in 22 Lombardy IVF Units. ResultsIn 2017, 29,718 procedures were performed, resulting in 4,543 pregnancies and 3,253 deliveries. In 2018, there were 29,708 procedures, 4,665 pregnancies and 3,348 deliveries. Pregnancies lost to follow up were 5.0% with a (range of 0 to 67.68%) in 2017 and 3.4% (range of 0 to 45.1%) in 2018. The cost reimbursement for the cycles were €2,232 ($2,611) for oocyte retrieval and €2,194 ($2,567) for embryo transfer, excluding ovarian stimulation therapy and luteal phase support.The mean multiple pregnancy delivery rate (MDR) in all 22 IVF centers was 11.08% ± 5,55% (range 0.00% -22.73%) in 2017 and 10.41% ± 4.99 (range 1.33% - 22.22%) in 2018. The mean cost for delivery in euros was 26,227 ± 14,737 in 2017 and 25,018 ± 16,039. The cost difference among centers was 12,480 - 76,725 in 2017 and 12,973 - 86,203 in 2018.Conclusions Our findings suggest the formulation of specific KPI’s (Key performance indexes) and minimal performance indexes (PI) as a basis for the allocation of public or insurance resources. In particular, the reduction of multiple pregnancy rates costs, may lead to a more widespread use of ART even in lower resources countries.