Single dose vitamin A treatment in acute shigellosis in Bangladeshi children: randomised double blind controlled trial

Hossain, Shahadat; Biswas, Rabi; Kabir, Iqbal; Sarker, Supta; Dibley, Michael J.; Fuchs, George J.; Mahalanabis, Dilip

doi:10.1136/bmj.316.7129.422

Cited by 54 publications

(29 citation statements)

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“…The estimates are also conservative because they do not account for reductions in morbidity associated with vitamin A supplementation. 3,4,[9][10][11][12][13][14][15][16][17][18] While the mortality impact estimates do not account for vitamin A supplements delivered as part of routine health services (which could decrease the impact of supplements provided during campaigns), it is likely that this effect is limited. Only 26 of 118 countries with a vitamin A deficiency problem reported to WHO in 1999 that they had integrated vitamin A supplements into their routine immunization services.…”

Section: Discussionmentioning

confidence: 99%

Childhood mortality impact and costs of integrating vitamin A supplementation into immunization campaigns

Ching

Birmingham²,

T³

et al. 2000

Am J Public Health

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Country-specific activity and coverage data were used to estimate the childhood mortality impact (deaths averted) and costs of integrating vitamin A supplements into immunization campaigns conducted in 1998 and 1999. More than 94 million doses of vitamin A were administered in 41 countries in 1998, helping to avert nearly 169,000 deaths. During 1999, delivery of more than 97 million doses in 50 countries helped avert an estimated 242,000 deaths. The estimated incremental cost per death averted was US$72 (range: 36-142) in 1998 and US$64 (range: 32-126) in 1999. The estimated average total cost of providing supplementation per death averted was US$310 (range: 157-609) in 1998 and US$276 (range: 139-540) in 1999. Costs per death averted varied by campaign, depending on the number and proportion of the child population reached, number of doses received per child, and child mortality rates.

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Section: Discussionmentioning

confidence: 99%

Childhood mortality impact and costs of integrating vitamin A supplementation into immunization campaigns

Ching

Birmingham²,

T³

et al. 2000

Am J Public Health

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“…In contrast, in another study in Bangladesh, children with shigellosis who received VA were less likely to be clinically ill by day 5 than were children given placebo (Hossain et al, 1998).…”

Section: Discussionmentioning

confidence: 80%

“…In contrast, clinical trials that have examined the effect of high-dose VA supplementation on diarrhoea and respiratory infections in children not infected with measles showed either no effects (Henning et al, 1992;Kjolhede et al, 1995;Nacul et al, 1997;Donnen et al, 1998;Fawzi et al, 1998;Faruque et al, 1999) or only small ones (Dewan et al, 1995;Si et al, 1997;Hossain et al, 1998;Julien et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Effect of daily low dose of vitamin A compared with single high dose on morbidity and mortality of hospitalized mainly malnourished children in senegal: a randomized controlled clinical trial

et al. 2007

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Background: In vitamin A-deficient populations, children hospitalized with infections and/or malnutrition are at particular risk of developing severe vitamin A (VA) deficiency. High-dose VA supplements are recommended as part of the treatment but results on its effect on recovery from morbidity and on prevention from nosocomial morbidity are conflicting. Objective: We aimed to assess the effect of a single high dose and daily low dose of VA on hospitalized malnourished children's morbidity. Design: We carried out a double-blind, randomized trial in 604 and 610 Senegalese hospitalized children. The first mentioned batch received a high-dose VA supplement (200 000 IU) on admission, the second a daily low-dose VA supplement (5000 IU per day) during hospitalization. Children were followed up until discharged. Data on all-cause morbidity were collected daily. Results: Survival analysis showed that the incidence of respiratory disease was significantly lower in the low-dose group than in the high-dose group, hazard ratios (HR): 0.26, 95% CI: 0.07-0.92. The duration of respiratory infection was also significantly lower in the low-dose group than in the high-dose group (HR of cure: 1.41, 95% CI: 1.05-1.89). Duration and incidence of diarrhoea were not significantly different between treatment groups. In children with oedema on admission, mortality was significantly lower in the low-dose group (Adjusted odds ratio: 0.21; 95% CI: 0.05-0.99). Conclusions: Daily low dose of VA compared with single high dose significantly reduced duration and incidence of respiratory infection but not of diarrhoea in hospitalized children.

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“…Algunos estudios sugieren que el uso terapéutico de vitamina A disminuye la duración de la diarrea (41,42). Sin embargo, existen varios estudios donde no se ha observado un beneficio (43)(44)(45).…”

Section: Vitamina Aunclassified

Diarrea y micronutrientes

Zea

Ochoa

2013

Rev Med Hered

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Single dose vitamin A treatment in acute shigellosis in Bangladeshi children: randomised double blind controlled trial

Cited by 54 publications

References 50 publications

Childhood mortality impact and costs of integrating vitamin A supplementation into immunization campaigns

Childhood mortality impact and costs of integrating vitamin A supplementation into immunization campaigns

Effect of daily low dose of vitamin A compared with single high dose on morbidity and mortality of hospitalized mainly malnourished children in senegal: a randomized controlled clinical trial

Diarrea y micronutrientes

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