Single-dose treatment with netilmicin for different clinical forms of urinary tract infections

Abstract

A group of 44 patients with various clinical forms of urinary tract infections received a single dose of 300 mg netilmicin i.m. The treatment was efficacious in all patients with infections which were negative in the antibody-coated bacteria test and not complicated by anatomic and/or functional abnormalities of the kidneys and urinary tract. After three weeks the recurrence rate was only 19%. Single-dose treatment also proved very effective against urinary tract infections in renal transplant patients whose infection is almost always located in the lower urinary tract. In contrast, the short-term results of treatment were much poorer in complicated infections and particularly in urinary tract infections which were positive in the anti-body-coated bacteria test; here, the recurrence rate was 67%.

A Systematic Review of Single-Dose Aminoglycoside Therapy for Urinary Tract Infection: Is It Time To Resurrect an Old Strategy?

“…Four Nine studies included patients with urinary malformations (e.g., vesicoureteral reflux; range, 0 to 50% of patients). Only one study reported the inclusion of patients with moderate and severe renal impairment (8/44 patients and 2/44 patients, respectively) (19).…”

“…Among the studies with adequate data, the percentage of patients with sustained microbiologic cure at 30 days was 73.4% Ϯ 9.6%. Among the studies providing comparisons of cure rates for patients with and without urinary tract abnormalities (11,12,14,19,20), patients with anatomical abnormalities were less likely to have initial microbiologic cure (86.3% versus 96.9%, P Ͻ 0.01), and, among studies with adequate data, were less likely to have sustained microbiologic cure at 30 days (57.3% versus 87.5%, P Ͻ 0.001). There was no significant difference in microbiologic cure rate in a comparison of pediatric-only studies (11-13, 18, 20, 22) and adult-only studies (15,17,19) (95% microbiologic cure rate and 94% microbiologic cure rate, respectively; P Ͼ 0.05).…”