Single-dose Treatment of Oxyuriasis with Pyrvinium Embonate

Desai, Anupam S.

doi:10.1136/bmj.2.5319.1583

Cited by 12 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To highlight this atom-efficient zeolite-catalyzed pyrrole synthesis, we focused our attention on the synthesis of a target compound of critical practical importance. Pyrrole-vinyl-quinoline (C) is the requisite precursor readily quarternized into pyrvinium, which is well-known for its anthelmintic functions against pinworms . Very lately, pyrvinium has also been confirmed to be highly effective in curing colon cancer by blocking a signaling pathway implicated in tumor cells .…”

Section: Results and Discussionmentioning

confidence: 99%

“…Pyrrole-vinylquinoline (C) is the requisite precursor readily quarternized into pyrvinium, which is well-known for its anthelmintic functions against pinworms. 24 Very lately, pyrvinium has also been confirmed to be highly effective in curing colon cancer by blocking a signaling pathway implicated in tumor cells. 25 A key step for the construction of C involves the synthesis of A, which is commonly achieved by the condensation of aniline with fossil-based 2,5-hexanedione (Scheme S3 in the Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Direct Synthesis of Pyrroles via Heterogeneous Catalytic Condensation of Anilines with Bioderived Furans

et al. 2016

View full text Add to dashboard Cite

Given the wide applications of pyrroles in agriculture, pharmaceuticals, and supramolecular and materials chemistry, a mild and eco-friendly route to produce functionalized pyrroles from bioderived feedstocks is highly desirable. Described herein is a mild and convenient synthesis of pyrroles via direct condensation of an equimolar amount of structurally diverse anilines with biobased furans catalyzed by a simple and efficient solid acid H form zeolite Y catalyst. The protocol tolerates a large variety of functional groups and offers a general and versatile method for scale-up synthesis of a variety of N-substituted pyrrole compounds. Most importantly, the bioactive pyrrole-derived drug pyrvinium, which has lately been confirmed as highly effective in curing colon cancer, can be obtained by this method.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Direct Synthesis of Pyrroles via Heterogeneous Catalytic Condensation of Anilines with Bioderived Furans

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The reduced toxicity of pyrvinium pamoate compared to pyrvinium chloride was likely due to reduced water solubility, which likely leads to decreased systemic gastrointestinal absorption [ 16 ]. PP thus became one of the primary treatments for various worm infestations for both human and veterinary use [ 14 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. With the advent of newer anti-parasitic agents, the utilization of PP as an anthelmintic in the United States gradually declined in the 1970s–1980s [ 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Pyrvinium Pamoate: Past, Present, and Future as an Anti-Cancer Drug

Schultz

2022

Biomedicines

View full text Add to dashboard Cite

Pyrvinium, a lipophilic cation belonging to the cyanine dye family, has been used in the clinic as a safe and effective anthelminthic for over 70 years. Its structure, similar to some polyaminopyrimidines and mitochondrial-targeting peptoids, has been linked with mitochondrial localization and targeting. Over the past two decades, increasing evidence has emerged showing pyrvinium to be a strong anti-cancer molecule in various human cancers in vitro and in vivo. This efficacy against cancers has been attributed to diverse mechanisms of action, with the weight of evidence supporting the inhibition of mitochondrial function, the WNT pathway, and cancer stem cell renewal. Despite the overwhelming evidence demonstrating the efficacy of pyrvinium for the treatment of human cancers, pyrvinium has not yet been repurposed for the treatment of cancers. This review provides an in-depth analysis of the history of pyrvinium as a therapeutic, the rationale and data supporting its use as an anticancer agent, and the challenges associated with repurposing pyrvinium as an anti-cancer agent.

show abstract

“…The IUPAC name of pyrvinium is 2‐([E]‐2‐[2,5‐Dimethyl‐1‐phenylpyrrol‐3‐yl]ethenyl)‐N,N,1‐trimethylquinolin‐1‐ium‐6‐amine, and its formula is C 26 H 28 N 3 + (Figure ). Pyrvinium is also available in combination with other counter anions such as embonate, triflate, halides, and tosylate (Desai, ; Mao, Lin, & Tian, ).…”

Section: Introductionmentioning

confidence: 99%

The novel role of pyrvinium in cancer therapy

Momtazi‐Borojeni

Abdollahi

Ghasemi

et al. 2017

Journal Cellular Physiology

View full text Add to dashboard Cite

Pyrvinium pamoate (PP) is a quinoline-derived cyanine dye which was officially approved by FDA for its anthelmintic properties and therapeutic function against animal-like protists such as Cryptosporidium parvum and Plasmodium falciparum in the 1950s. In the last 10 years, several studies have shown the novel activity of pyrvinium in tumor therapy. Some investigations have indicated that pyrvinium could delay or inhibit tumor cell proliferation in cancer models including colon, breast, lung and prostate cancer, and some hematological malignancies. In this review, we discuss multiple critical signaling pathways and mechanisms underlying the anticancer effects of PP. In details, pyrvinium acts through the following main mechanisms: (i) energy and autophagy depletion; and (ii) inhibition of Akt and Wnt-β-catenin-dependent pathways. Interestingly, pyrvinium has also shown potent anti-cancer stem cell activity. The overwhelming insights into the mechanism of anticancer properties of PP can help establishing novel and future anti-tumor treatment strategies.

show abstract

Single-dose Treatment of Oxyuriasis with Pyrvinium Embonate

Cited by 12 publications

References 4 publications

Direct Synthesis of Pyrroles via Heterogeneous Catalytic Condensation of Anilines with Bioderived Furans

Direct Synthesis of Pyrroles via Heterogeneous Catalytic Condensation of Anilines with Bioderived Furans

Pyrvinium Pamoate: Past, Present, and Future as an Anti-Cancer Drug

The novel role of pyrvinium in cancer therapy

Contact Info

Product

Resources

About