Single-Dose Prophylactic Antibiotic Versus Extended Usage for Four Days in Clean-Contaminated Oncological Surgeries: a Randomized Clinical Trial

Nusrath, Syed; Nair, Abhijit; Dasu, Sridhar; Rao, T. Subramanyeshwar; Raju, K. V. V. N.; Rayani, Basanth Kumar; Naik, Vibhavari; Patnaik, Sujit Chyau; Iyer, R. Rajagopalan; Saksena, Ajesh Raj; Rao, Mayank; Saifuddin, Salman; Narayanan, Harini; Dandamudi, Radha Rani; Gupta, Naresh

doi:10.1007/s13193-020-01163-x

Cited by 3 publications

(2 citation statements)

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“…In addition, this study reported a higher incidence of remote infection in the single-dose group. However, the analysis and results showed that the single-dose antimicrobial prophylaxis was as efficacious as the multiple-dose regimen in controlling the SSIs [16].…”

Section: Colorectal Oncological Surgery: the Role Of Antimicrobial Prophylaxis And Addition Of Metronidazole To The Regimenmentioning

confidence: 95%

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Is Single-Dose Antimicrobial Prophylaxis Sufficient to Control Infections in Gastrointestinal Oncological Surgeries?

Kannan

Ravichandran

Sundaramurthi

et al. 2021

Cureus

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Surgical site infections (SSIs) represent one of the most important complications occurring postoperatively following surgical procedures. The SSI incidence is higher following gastrointestinal (GI) surgeries compared to any other surgery. It contributes to the majority of morbidity and mortality in patients undergoing GI surgeries. The accepted practice worldwide for the prevention and control of SSIs is providing antimicrobial prophylaxis. The appropriate antimicrobial and dose are chosen depending on the microbial flora, complications, and patient risk factors. The objective of this review was to determine the sufficient number of prophylactic antimicrobial doses that would be efficacious and safe in controlling the SSIs following GI oncological surgeries. Single-dose antimicrobial prophylaxis has shown the same efficacy as the multipledose antimicrobial regimen in controlling SSIs in esophageal, gastric, and colorectal surgeries. The advantages of a single-dose regimen include less chance of emergence of resistance, less chance for allergies or toxicity, and less cost. The addition of metronidazole with single-dose antimicrobial prophylaxis in colorectal surgery should be considered due to its beneficial effect in further reducing infections. Further randomized controlled trials are needed for the literature to determine the efficacy and safety of single-dose antimicrobial prophylaxis in patients undergoing esophageal and colorectal surgeries. In addition, studies are required to determine the individual effectiveness of metronidazole in controlling SSIs in colorectal surgeries.

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Section: Colorectal Oncological Surgery: the Role Of Antimicrobial Prophylaxis And Addition Of Metronidazole To The Regimenmentioning

confidence: 95%

“…FIGURE 2: Risk of bias in the included randomized controlled trials D, domainThe randomized controlled trials included for the risk of bias assessment are studies by Mohri et al[11], Haga et al[12], Imamura et al[13], Ahn and Lee[14], Fujita et al[15], and Nusrath et al[16].…”

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confidence: 99%