Single‐Dose Pharmacokinetics of Cetirizine in Patients With Chronic Liver Disease

Horsmans, Yves; Desager, Jean‐Pierre; Hulhoven, R.; Harvengt, C.

doi:10.1002/j.1552-4604.1993.tb01924.x

Cited by 24 publications

(11 citation statements)

References 5 publications

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“…administration. Similar results were reported in the pharmacokinetic study of cetirizine, which had a T max of 1.09 h in the healthy volunteers and 2.50 h for the patients (Horsmans et al ., ). The function of the cardiac pump could be weakened by pericarditis, thereby disturbing the microcirculation (Dudzinski, et al .…”

Section: Pharmacokinetic Parameters Of Valnemulin Following Im and mentioning

confidence: 99%

Mycoplasma gallisepticum and Escherichia coli mixed infection model in broiler chickens for studying valnemulin pharmacokinetics

Xiao

Zhao

Yang

et al. 2013

Vet Pharm & Therapeutics

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A Mycoplasma gallisepticum-Escherichia coli mixed infection model was developed in broiler chickens, which was applied to pharmacokinetics of valnemulin in the present experiment. The velogenic M. gallisepticum standard strain S6 was rejuvenated to establish the animal model, and the wild E. coli strain O78 was injected as supplementary inoculum to induce chronic respiratory disease in chickens. The disease model was evaluated based on its clinical signs, histopathological examination, bacteriological assay, and serum plate agglutination test. The pharmacokinetics of valnemulin in infected chickens was determined by intramuscular (i.m.) injection and oral administration (per os, p.o.) of a single dose of 10 mg/kg body weight (BW). Plasma samples were analyzed by liquid chromatography-tandem mass spectrometry. The plasma concentration-time curve of valnemulin was analyzed using the noncompartmental method. After the i.m. administration, the mean values of Cmax , Tmax , AUClast , MRT, CLβ /F, Vz /F, and t1⁄2β , were 27.94 μg/mL, 1.57 h, 171.63 μg·h/mL, 4.51 h, 0.06 L/h/kg, 0.56 L/kg, and 6.50 h, respectively. By contrast, the corresponding values after p.o. administration were 5.93 μg/mL, 7.14 h, 47.60 μg·h/mL, 9.80 h, 0.22 L/h/kg, 3.35 L/kg, and 10.60 h. The disposition of valnemulin was retarded in infected chickens after both modes of extravascular administration as compared to the healthy controls. More attention should be given to monitoring the therapeutic efficacy and adverse effects of mixed infection because of higher required plasma drug concentration and enlarged AUC with valnemulin treatment.

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Section: Pharmacokinetic Parameters Of Valnemulin Following Im and mentioning

confidence: 99%

Mycoplasma gallisepticum and Escherichia coli mixed infection model in broiler chickens for studying valnemulin pharmacokinetics

Xiao

Zhao

Yang

et al. 2013

Vet Pharm & Therapeutics

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“…Cetirizine and fexofenadine differ from the other non‐sedative antihistamines because they are eliminated primarily by renal excretion of the parent drug with little metabolism [2]. In consequence the drug interactions critical for terfenadine and astemizole would not be relevant, and renal disease rather than liver disease could result in elevated plasma concentrations, although increased AUC values and longer half‐lives have been reported in patients with chronic liver disease [31]. However, cetirizine was without ECG effects even after dosage for 7 days [32], indicating negligible risk of adverse cardiac effects.…”

Section: Cardiac Side‐effects Of Antihistaminesmentioning

confidence: 99%

The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes

Renwick¹

1999

Clin Experimental Allergy

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The non-sedating antihistamines show a diversity of fates in the body and the parent drugs and metabolites may differ in their biological properties. Clinically significant interactions with inhibitors of cytochrome P450 have been reported primarily for terfenadine, which has the potential for cardiac toxicity, and is metabolized to fexofenadine, an antihistamine without cardiac effects. Astemizole shares many of these characteristics and important safety-related interactions are likely. Loratadine undergoes extensive metabolism so that pharmacokinetic interactions could occur, but they would be of little clinical importance because of the lack of cardiac activity of the parent drug and its metabolites. Ebastine also undergoes pharmacokinetic interactions, the significance of which is dependent on clarification of the extent of any relevant cardiotoxicity of both ebastine and its metabolite. Interactions would not be clinically important for cetirizine and fexofenadine which do not show cardiac effects and are eliminated with little metabolism.

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“…The elimination half-life of CTZ was prolonged in patients with renal and chronic liver insufficiency, compared with age-matched individuals with normal renal function (19.0-20.9 vs. 7.4 h, respectively). (1819). …”

Section: Discussionmentioning

confidence: 99%

Oral Bioavailability and Pharmacokinetic Study of Clarithromycin in Different Dosage Forms in Iranian Healthy Volunteers

Derakhshandeh¹

2014

J Bioequiv Availab

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The objective of the present study was to evaluate the pharmacokinetic parameters and bioavailability of a selective histamine (H1)-receptor antagonist, cetirizine hydrochloride (CTZ), following administration of a single oral dose of the drug. The properties of a test compound were compared with those of a reference product in a randomized cross-over study in 12 volunteers. Blood samples were collected at selected time intervals up to 24 h and plasma concentrations of CTZ were determined using a validated HPLC method. Pharmacokinetic parameters including T1/2, T1/2(abs), K, Ka, Tmax, Cmax, Vd/F, Cl/F, AUC0-24, AUC 0-∞ and MRT were determined from plasma concentration-time profiles for tested products and found to be in good agreement with previous reports. The analysis of variance did not show any significant differences between the test and reference products. The confidence intervals for the ratio of Cmax (95-110%), AUC0-24 (91-112%) and AUC0-∞ (92-109%) for the test and reference products were within the acceptable interval of 80-125%. ANOVA assessment of logarithmically transformed data did not reveal any significant subject, period or sequence effects. It was, therefore, concluded that the two products were bioequivalent and could be used interchangeably.

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Single‐Dose Pharmacokinetics of Cetirizine in Patients With Chronic Liver Disease

Cited by 24 publications

References 5 publications

Mycoplasma gallisepticum and Escherichia coli mixed infection model in broiler chickens for studying valnemulin pharmacokinetics

Mycoplasma gallisepticum and Escherichia coli mixed infection model in broiler chickens for studying valnemulin pharmacokinetics

The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes

Oral Bioavailability and Pharmacokinetic Study of Clarithromycin in Different Dosage Forms in Iranian Healthy Volunteers

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