Single dose oral diclofenac for acute postoperative pain in adults

Abstract

Diclofenac potassium provides good pain relief at 25 mg, 50 mg, and 100 mg doses. Diclofenac sodium has limited efficacy and should probably not be used in acute pain.

Comparison of paracetamol, ibuprofen, and diclofenac potassium for pain relief following dental extractions and deep cavity preparations

“…Patients in the fast dissolving paracetamol 1000 mg group reported less postoperative pain and increased time to first rescue analgesics than patients in either the normal dose of paracetamol 500 mg or fast dissolving paracetamol 500 mg tablets groups. The current study result is similar to the findings from the study by Derry et al, 24 who reported that the clinical advantages for using fast-dissolving and absorbed diclofenac potassium is including better pain relief than those that are absorbed slowly. They concluded that diclofenac potassium at 50 mg single dose is considered as a good pain relief for moderate postoperative pain in adults.…”

Diclofenac for pain associated with intravitreal injections: a prospective, randomized, placebo‐controlled study

“…For instance, ketorolac 0.1% and bromfenac 0.9% ophthalmic solutions instilled prior the IVIs, as well as nepafenac 0.1% eye drops administered after the IVIs, were proven effective in decreasing pain perception associated with IVIs . Diclofenac is a benzene acetic acid derivative and is one of the most widely used NSAIDs in clinical practice that acts by inhibiting the COX‐1 and COX‐2 isoenzymes that catalyse the initial step of arachidonic acid metabolism and prostaglandin production . The oral form is a potent anti‐inflammatory and analgesic agent effective in treating a variety of inflammatory conditions as well as acute and chronic painful conditions including post‐traumatic or postoperative pain, even given as a single dose in the pharmacotechnical form of prolonged release tablets .…”

“…12,18,19 Diclofenac is a benzene acetic acid derivative and is one of the most widely used NSAIDs in clinical practice that acts by inhibiting the COX-1 and COX-2 isoenzymes that catalyse the initial step of arachidonic acid metabolism and prostaglandin production. 9 The oral form is a potent anti-inflammatory and analgesic agent effective in treating a variety of inflammatory conditions as well as acute and chronic painful conditions including post-traumatic or postoperative pain, even given as a single dose in the pharmacotechnical form of prolonged release tablets. 20 Diclofenac eye drops are indicated for inhibition of miosis during cataract surgery, for treatment of postoperative inflammation after cataract surgery, control of ocular pain and discomfort associated with corneal refractive surgery or strabismus surgery, for control of inflammation after laser trabeculoplasty and for relief of the ocular signs and symptoms of seasonal allergic conjunctivitis.…”

“…Diclofenac is a benzene acetic acid derivative and is available for both systemic and topical administration in the form of ophthalmic drops. Orally administered diclofenac has been used for postoperative pain relief . Diclofenac, in the form of ophthalmic drops, is commonly used as anti‐inflammatory and analgesic agent in ophthalmology .…”

“…Orally administered diclofenac has been used for postoperative pain relief. 9 Diclofenac, in the form of ophthalmic drops, is commonly used as antiinflammatory and analgesic agent in ophthalmology. 8 The purpose of this study is to evaluate the effect of topical diclofenac administered alone or combined with oral diclofenac, on reducing IVI-associated pain in patients undergoing treatment with anti-VEGF agents.…”