Single-dose intravenous administration of antiepileptic drugs induces rapid and reversible remodeling in the brain: Evidence from a voxel-based morphometry evaluation of valproate and levetiracetam in rhesus monkeys

Tang, YH; Yu, Xiaofeng; Zhang, X.; Xia, Wei; Wu, Xintong; Zou, Xinyu; Li, H.; Huang, Xiaoqi; Stefan, Hermann; Chen, Q.; Gong, Qiyong; Zhou, Dong

doi:10.1016/j.neuroscience.2015.07.039

Cited by 18 publications

(12 citation statements)

References 59 publications

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“…These data resonate with other reports of acute administration of baclofen [Franklin et al, ], lithium [Cousins et al, ] and even cigarette smoking [Franklin et al, ] causing apparent rapid localized changes in GM volume or density. Similar reversible changes following single doses of either sodium valproate or levetiracetam have been reported in rhesus monkeys [Tang et al, ]. Changes on this time scale are not limited to pharmacological interventions—other factors such as dehydration [Duning et al, ; Kempton et al, ], learning [Kwok et al, ], and environmental enrichment [Scholz et al, ] have been shown to rapidly influence in vivo measures of brain volume when measured using longitudinal MRI.…”

Section: Introductionmentioning

confidence: 68%

An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers

Hawkins

Wood

Vernon

et al. 2017

Human Brain Mapping

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Chronic administration of antipsychotic drugs has been linked to structural brain changes observed in patients with schizophrenia. Recent MRI studies have shown rapid changes in regional brain volume following just a single dose of these drugs. However, it is not clear if these changes represent real volume changes or are artefacts ("apparent" volume changes) due to drug-induced physiological changes, such as increased cerebral blood flow (CBF). To address this, we examined the effects of a single, clinical dose of three commonly prescribed antipsychotics on quantitative measures of T1 and regional blood flow of the healthy human brain. Males (n 5 42) were randomly assigned to one of two parallel groups in a double-blind, placebo-controlled, randomized, three-period cross-over study Additional Supporting Information may be found in the online version of this article. design. One group received a single oral dose of either 0.5 or 2 mg of risperidone or placebo during each visit. The other received olanzapine (7.5 mg), haloperidol (3 mg), or placebo. MR measures of quantitative T1, CBF, and T1-weighted images were acquired at the estimated peak plasma concentration of the drug. All three drugs caused localized increases in striatal blood flow, although drug and region specific effects were also apparent. In contrast, all assessments of T1 and brain volume remained stable across sessions, even in those areas experiencing large changes in CBF. This illustrates that a single clinically relevant oral dose of an antipsychotic has no detectable acute effect on T1 in healthy volunteers. We further provide a methodology for applying quantitative imaging methods to assess the acute effects of other compounds on structural MRI metrics. Hum Brain Mapp 39:319-331, 2018.V C 2017 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 68%

An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers

Hawkins

Wood

Vernon

et al. 2017

Human Brain Mapping

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“…Fifth, most of our participants were medication free but not medication naïve, which limits generalization to medication‐naïve subjects. Despite evidence of reversibility of (volumetric) medication effects, we cannot rule out the possibility that our results are influenced by the long‐term effects of previous medication. Sixth, we have no reliable information regarding handedness, which may differ between groups.…”

Section: Discussionmentioning

confidence: 99%

“…Fifth, most of our participants were medication free but not medication naïve, which limits generalization to medication-naïve subjects. Despite evidence of reversibility of (volumetric) medication effects, 102,103 we cannot rule out the possibility that our results are influenced by the long-term effects of F I G U R E 2 Weight maps of depressed major depressive disorder (MDDd) vs depressed bipolar disorder (BDd) classification. Weight maps are based on the default mode network and gray matter data.…”

Section: Bd-ii May Be Considered As An Intermediate Between Bd-i and Mddmentioning

confidence: 96%

Distinguishing medication‐free subjects with unipolar disorder from subjects with bipolar disorder: state matters

et al. 2016

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For the first time, we showed that medication-free subjects with MDD and BD can be differentiated based on structural MRI as well as resting-state functional connectivity. Importantly, the results indicated that research concerning diagnostic neuroimaging tools distinguishing between MDD and BD should consider mood state as only depressed subjects with MDD and BD could be correctly classified. Future studies, in larger samples are needed to investigate whether the results can be generalized to medication-naïve or first-episode subjects.

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“…The ROI method involves tracing the object manually in many slices leading to bias ( 2 ). VBM analysis was used in some animal models, such as mice ( 3 ), rats ( 4 ), baboons ( 5 ), and macaques ( 6 ). Dogs were also used as human models of aging in VBM studies ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Statistical Structural Analysis of Familial Spontaneous Epileptic Cats Using Voxel-Based Morphometry

Hamamoto

Hasegawa

et al. 2018

Front. Vet. Sci.

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Voxel-based morphometry (VBM) based on high resolution three-dimensional data of magnetic resonance imaging has been developed as a statistical morphometric imaging analysis method to locate brain abnormalities in humans. Recently, VBM has been used for human patients with psychological or neurological disorders such as Alzheimer's disease, Parkinson's disease, and epilepsy. Traditional volumetry using region of interest (ROI) is performed manually and the observer needs detailed knowledge of the neuroanatomy having to trace objects of interest on many slices which can cause artificial errors. In contrast, VBM is an automatic technique that has less observer biases compared to the ROI method. In humans, VBM analysis is performed in patients with epilepsy to detect accurately structural abnormalities. Familial spontaneous epileptic cats (FSECs) have been developed as an animal model of mesial temporal lobe epilepsy. In FSECs, hippocampal asymmetry had been detected using three-dimensional magnetic resonance (MR) volumetry based on the ROI method. In this study, we produced a standard template of the feline brain and compared FSECs and healthy cats using standard VBM analysis. The feline standard template and tissue probability maps were created using 38 scans from 14 healthy cats. Subsequently, the gray matter was compared between FSECs (n = 25) and healthy controls (n = 12) as group analysis and between each FSEC and controls as individual analysis. The feline standard template and tissue probability maps could be created using the VBM tools for humans. There was no significant reduction of GM in the FSEC group compared to the control group. However, 5/25 (20%) FSECs showed significant decreases in the hippocampal and/or amygdaloid regions in individual analysis. Here, we established the feline standard templates of the brain that can be used to determine accurately abnormal zones. Furthermore, like MR volumetry, VBM identified morphometric changes in the hippocampus and/or amygdala in some FSECs.

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Single-dose intravenous administration of antiepileptic drugs induces rapid and reversible remodeling in the brain: Evidence from a voxel-based morphometry evaluation of valproate and levetiracetam in rhesus monkeys

Cited by 18 publications

References 59 publications

An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers

An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers

Distinguishing medication‐free subjects with unipolar disorder from subjects with bipolar disorder: state matters

Statistical Structural Analysis of Familial Spontaneous Epileptic Cats Using Voxel-Based Morphometry

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