Single-dose intra-articular corticosteroid injection prior to platelet-rich plasma injection resulted in better clinical outcomes in patients with knee osteoarthritis: A pilot study

Çamurcu, Yalkın; Sofu, Hakan; Üçpunar, Hanifi; Koçkara, Nizamettin; Cobden, Adem; Duman, Serda

doi:10.3233/bmr-171066

Cited by 19 publications

(17 citation statements)

References 29 publications

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“…The authors have pointed out that the lack of control group, small sample size and lack of morphological assessments are among their study limitations [57]. As reported in a recent study, intra-articular injection of corticosteroids prior to PRP injection resulted in better outcomes in patients with mild to moderate OA [58]. Aside from studies including patients with knee OA, some randomized trials are also existed about other affected tissues like hip and ankle.…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

The use of stromal vascular fraction (SVF), platelet-rich plasma (PRP) and stem cells in the treatment of osteoarthritis: an overview of clinical trials

Mehranfar

Rad

Mostafav

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Section: Platelet-rich Plasmamentioning

confidence: 99%

The use of stromal vascular fraction (SVF), platelet-rich plasma (PRP) and stem cells in the treatment of osteoarthritis: an overview of clinical trials

Mehranfar

Rad

Mostafav

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…PRP was reported as better in terms of clinical improvement compared to oral NSAID administration [161], as synergistic and protective, when added to methylprednisolone [150] and comparable to HA and corticosteroids after three months, superior to both the other treatments in the long-term [149].…”

Section: Knee Osteoarthritismentioning

confidence: 92%

Platelet Concentrates in Musculoskeletal Medicine

Mariani

Pulsatelli

2020

IJMS

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Platelet concentrates (PCs), mostly represented by platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous biological blood-derived products that may combine plasma/platelet-derived bioactive components, together with fibrin-forming protein able to create a natural three-dimensional scaffold. These types of products are safely used in clinical applications due to the autologous-derived source and the minimally invasive application procedure. In this narrative review, we focus on three main topics concerning the use of platelet concentrate for treating musculoskeletal conditions: (a) the different procedures to prepare PCs, (b) the composition of PCs that is related to the type of methodological procedure adopted and (c) the clinical application in musculoskeletal medicine, efficacy and main limits of the different studies.

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“…In addition, a pilot study evaluating the utility of combining CS and PRP showed a synergistic effect, with significantly lower WOMAC (at 1 and 3 months) and VAS (at 1, 3, and 6 months) scores in the combined group compared to PRP or CS alone. However, the benefits were no longer apparent at 12 months postinjection [34]. Based on these results, PRP may be a more effective treatment option for patients with moderate knee OA than CS with respect to pain relief and quality of life, and while more research is needed, the two interventions may have a synergistic effect at pain and disability reduction.…”

Section: Comparison To Other Treatments In Oamentioning

confidence: 92%

Platelet-Rich Plasma and the Knee—Applications in Orthopedic Surgery

Wasserman

Matthewson

MacDonald

2018

Curr Rev Musculoskelet Med

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PRP has been shown to be more beneficial in the context of knee osteoarthritis compared to both placebo and hyaluronic acid. Direct comparison with corticosteroid injections has been sparsely studied. It has also been shown to improve the clinical postoperative course in meniscal injuries and to a lesser extent TKA. Radiographic improvements without clinically significant benefits have been observed with ACL reconstructions treated with PRP. PRP injections may be more beneficial than other current non-surgical management options for specific knee pathologies. Further research should broaden the knowledge of PRP effects on the knee, and identify the type of PRP, growth factor distribution, and route of administration associated with the most benefit.

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Single-dose intra-articular corticosteroid injection prior to platelet-rich plasma injection resulted in better clinical outcomes in patients with knee osteoarthritis: A pilot study

Abstract: According to our results, IA MP injection prior to PRP injection resulted in significantly better clinical outcomes compared to PRP and MP injections alone in patients who had mild to moderate knee OA.

Cited by 19 publications

References 29 publications

The use of stromal vascular fraction (SVF), platelet-rich plasma (PRP) and stem cells in the treatment of osteoarthritis: an overview of clinical trials

The use of stromal vascular fraction (SVF), platelet-rich plasma (PRP) and stem cells in the treatment of osteoarthritis: an overview of clinical trials

Platelet Concentrates in Musculoskeletal Medicine

Platelet-Rich Plasma and the Knee—Applications in Orthopedic Surgery

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