Single-dose i.v. dexamethasone?an effective anti-emetic in cancer chemotherapy

Abstract

We conducted a randomised, single-blind, placebo-controlled crossover study to assess the efficacy of a single i.v. dose of 20 mg dexamethasone as an anti-emetic in 31 patients receiving cancer chemotherapy. Patients receiving dexamethasone experienced significantly less nausea and vomiting (P less than 0.001 and P less than 0.01, respectively), and appetite and activity were normal in a majority of the treated group. Side effects were insignificant. We conclude that single-dose dexamethasone given i.v. at a dose of 20 mg is a safe and effective anti-emetic for patients receiving cancer chemotherapy excluding cisplatin.

The Effect of Single Dose Intravenous Dexamethasone in Tonsillectomy in Children

“…In recent years there has been considerable interest in dexamethasone for reducing postoperative nausea and vomiting. Although the mechanism of its antiemetic effect is not known, dexamethasone has been used as an antiemetic drug during chemotherapy in oncology patients [2][3][4] . Dexamethasone has a long duration of action with a biological half-life up to 72 hours 5 .…”

CCL5 promotes the proliferation and metastasis of bladder cancer via the JAK2/STAT3 signaling pathway

“…Expression of this protein is found in T lymphocytes, macrophages, platelets, synovial fibroblasts, tubule epithelial cells, and tumor cells ( 17 ). According to recent studies, CCL5 promotes tumor progression by enhancing tumor metastasis ( 18 ) and remodeling the extracellular matrix, which results in supporting tumor stem cell expansion ( 19 ), causing tumor cells drug-resistant ( 20 ), reducing the cytotoxicity of DNA damage factors, decompressing cellular metabolic reprogramming ( 21 ), increasing angiogenesis, mobilizing immune cells ( 22 ), and inducing macrophage polarization to suppress immune response ( 23 ). However, the underlying mechanism of CCL5 in BC remains unclear.…”

Pulsed steroid therapy is an effective treatment for intractable hyperemesis gravidarum

“…Arising from the speculation that severe nausea and vomiting of pregnancy may result from adrenocorticotropic hormone deficiency (2) and from the successful use of steroids for chemotherapyinduced emesis (3,4), studies have been conducted on various steroid therapy regimes in hyperemesis demonstrating significant benefits of steroids in respect to well-being, food intake, and weight gain (1,2,5).…”