Single-Dose Antibiotic Treatment for Uncomplicated Urinary Tract Infections

Treatment of acute uncomplicated urinary tract infections with 3 days of lomefloxacin compared with treatment with 3 days of norfloxacin

“…While short courses of therapy may be minimally less effective than longer courses of therapy of 7 to 14 days, the increased adverse effects associated with longer courses of therapy make short courses of therapy the treatment of choice. For trimethoprim-sulfamethoxazole, single-dose therapy is likely optimal (4,12,15). For other antimicrobial agents effective as short courses of therapy, 3 days of therapy has been suggested to be appropriate (6,8,9,16).…”

Treatment duration for urinary tract infections in adults

“…There are obvious advantages to this therapeutic program: enhanced compliance, reduced cost and side effects, and lessened selective microbial pressure on the periurethral and rectal tissues. Another potential value of single-dose treatment of acute bacterial cystitis (diagnosed by conventional clinical criteria) is that failure to achieve an immediate bacteriologic response, determined by persistent bacteriuria 2 (40). A prospective randomized study performed at the Mayo Clinic did enter adequate numbers of patients into a clinical study, and the authors of the report of this-research concluded that higher cure rates were achieved with a 10-day treatment course (44).…”

Bacterial Host Interaction in the Pathogenesis and Management of Lower Urinary Tract Infection

“…A synergy between antibodies and small amounts of antibacterial agents may also explain why the urine is sterile after treatment of UTI with single doses of antibi otics [Svanborg-Eden et al, 1981]: this may constitute the basis for the use of single-dose therapy in UTIs. In recent years, numerous studies have attempted to define an effective, nontoxic, easily administered and inexpen sive therapeutic regimen in the form of a single oral dose [Brumfitt et al, 1970;Cardenas et al, 1986;Philbrick and Bracikowski, 1985;Schultz et al, 1984;Souney and Polk, 1982]. The clinical efficacy of various drugs used in a single dose for treating acute UTI has been docu mented in numerous reports.…”

“…The clinical efficacy of various drugs used in a single dose for treating acute UTI has been docu mented in numerous reports. Single-dose sulfamethoxa zole-trimethoprim has been reported to be as effective [Philbrick and Bracikowski, 1985] as cephalexin [Car …”