Single-dose antibiotic prophylaxis is effective enough in colorectal surgery

Ahn, Byung Kyu; Lee, Kang Hong

doi:10.1111/j.1445-2197.2012.06244.x

Cited by 15 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the number of doses was not found as an independent risk factor for SSIs. The crucial point to consider in this RCT is the addition of metronidazole along with the first-line agent in both groups [14].…”

Section: Colorectal Oncological Surgery: the Role Of Antimicrobial Prophylaxis And Addition Of Metronidazole To The Regimenmentioning

confidence: 99%

See 1 more Smart Citation

Is Single-Dose Antimicrobial Prophylaxis Sufficient to Control Infections in Gastrointestinal Oncological Surgeries?

Kannan

Ravichandran

Sundaramurthi

et al. 2021

Cureus

View full text Add to dashboard Cite

Surgical site infections (SSIs) represent one of the most important complications occurring postoperatively following surgical procedures. The SSI incidence is higher following gastrointestinal (GI) surgeries compared to any other surgery. It contributes to the majority of morbidity and mortality in patients undergoing GI surgeries. The accepted practice worldwide for the prevention and control of SSIs is providing antimicrobial prophylaxis. The appropriate antimicrobial and dose are chosen depending on the microbial flora, complications, and patient risk factors. The objective of this review was to determine the sufficient number of prophylactic antimicrobial doses that would be efficacious and safe in controlling the SSIs following GI oncological surgeries. Single-dose antimicrobial prophylaxis has shown the same efficacy as the multipledose antimicrobial regimen in controlling SSIs in esophageal, gastric, and colorectal surgeries. The advantages of a single-dose regimen include less chance of emergence of resistance, less chance for allergies or toxicity, and less cost. The addition of metronidazole with single-dose antimicrobial prophylaxis in colorectal surgery should be considered due to its beneficial effect in further reducing infections. Further randomized controlled trials are needed for the literature to determine the efficacy and safety of single-dose antimicrobial prophylaxis in patients undergoing esophageal and colorectal surgeries. In addition, studies are required to determine the individual effectiveness of metronidazole in controlling SSIs in colorectal surgeries.

show abstract

Section: Colorectal Oncological Surgery: the Role Of Antimicrobial Prophylaxis And Addition Of Metronidazole To The Regimenmentioning

confidence: 99%

“…FIGURE 2: Risk of bias in the included randomized controlled trials D, domainThe randomized controlled trials included for the risk of bias assessment are studies by Mohri et al[11], Haga et al[12], Imamura et al[13], Ahn and Lee[14], Fujita et al[15], and Nusrath et al[16].…”

mentioning

confidence: 99%

Is Single-Dose Antimicrobial Prophylaxis Sufficient to Control Infections in Gastrointestinal Oncological Surgeries?

Kannan

Ravichandran

Sundaramurthi

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…49 Prophylaxis with short-term antibiotic reduced infections from 30%-50% to 11% or less. [50][51][52] Patients at risk for ostomy must receive adequate counselling before surgery. The site of the ostomy should be marked prior to surgery on the skin of the standing patient.…”

Section: Strong Against Lowmentioning

confidence: 99%

Management of patients with early-stage colon cancer: guidelines of the Italian Medical Oncology Association

et al. 2020

View full text Add to dashboard Cite

About 75% of colorectal cancers are diagnosed as early stage, in which radical surgery is achievable. In the last decade, in Italy, the overall incidence of colorectal cancer has remained stable, while mortality gradually decreased, which is attributable to early diagnosis and improved medical, surgical and locoregional treatments. The Italian Medical Oncology Association formulated guidelines to manage early-stage colon cancer, including screening, diagnosis, treatment and follow-up, which we herein present.

show abstract

“…Gram-positive, Gramnegative bacterias, facultative anaerobic bacilli (e.g.Escherichia coli) and obligate anaerobes (e.g. Bacteroides fragilis) are the most common microorganisms involved in colorectal postoperatory SSIs [16]. In the past, mechanical bowel preparation (MBP) was the only method used to prevent infectious complications.…”

Section: Colorectal Surgerymentioning

confidence: 99%

“…Second-generation cephalosporins should be used against Gramposivive and Gram-negative organisms, but they are not effective against obligate anaerobes. Thus, a combination of second-generation cephalosporins and metronidazole is adequate to cover all microorganisms involved in infectious complications after colorectal surgery [16]. According to guidelines, best association of antibiotics is cefotixin, 2g, with a recommended redosing interval of 2 h, + metronidazole, 500mg, or clindamycin ( 900 mg) + aminoglycoside or aztreonan ( 2g) or fluoroquinolone for the patients who are allergic to β-lactam [8].…”

Section: Colorectal Surgerymentioning

confidence: 99%

Antibioprophylaxis and Antibiotherapy in Abdominal Surgery – Short Review

Leontescu

Andronic

Păduraru

et al. 2019

RJCR

View full text Add to dashboard Cite

Surgical site infection (SSI) represents a concerning for all surgeons because both the unfavorable impact on health care costs and risk factors that increase the durations of wound healing and SSI rate. A review of PubMed, Scopus and Google Scholar has been made. The keywords used were related to surgical site infection prevetion. SSIs have a raised incidence in abdominal surgery because of the fact that many types of bacterias live in the gastrointestinal tract and during a surgical procedure some may escape and cause an infection. There is a high risk of postoperatory infections in gastric surgery due to intestinal anastomoses which are predisposed to leakage. In hernia repair surgery there is a higher rate of SSIs than expected for a clean procedure, and one risk factor may be represented by the prosthetic device used. On the other hand, in laparoscopic cholecystectomy, there is a very low risk of SSI and antibioprophylaxis is not recommended. But the most contaminated procedure with the highest risk of infectious complications is colorectal surgery, which requieres a combination of antibiotics because of the numerous types of microorganism. Abdominal surgery comprises different techniques and involves most elements of the gastrointestinal tract. Some procedures need antibiotic prophylaxis and in others antibiotic administration is even prohibited. The most effective antibiotics are first and second-generation cephalosporins.

show abstract

Single-dose antibiotic prophylaxis is effective enough in colorectal surgery

Abstract: SD antibiotic prophylaxis with second-generation cephalosporin and metronidazole is equivalent to a three-dose prophylaxis for preventing SSI in elective colorectal surgery. But further study would be needed to clarify this because of the small number of participants.

Cited by 15 publications

References 20 publications

Is Single-Dose Antimicrobial Prophylaxis Sufficient to Control Infections in Gastrointestinal Oncological Surgeries?

Is Single-Dose Antimicrobial Prophylaxis Sufficient to Control Infections in Gastrointestinal Oncological Surgeries?

Management of patients with early-stage colon cancer: guidelines of the Italian Medical Oncology Association

Antibioprophylaxis and Antibiotherapy in Abdominal Surgery – Short Review

Contact Info

Product

Resources

About