Single-dose and 13-week repeated-dose neurotoxicity screening studies of chlorpyrifos insecticide

Mattsson, Joel L.; Wilmer, J.W.G.M.; Shankar, M.R.; Berdasco, N.M.; Crissman, James W.; Maurissen, Jacques P.J.; Bond, Denise M.

doi:10.1016/0278-6915(96)00121-4

Cited by 36 publications

(8 citation statements)

References 19 publications

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“…On the other hand, adolescent rats exposed to CPF showed conflicting results in their motor activities level. While some studies reported no alteration in the motor activity [[26], [27], [28]], other studies reported a transient decrease in motor activity due to subchronic dietary exposure [29] and an impairment of motor function manifested in decline in hindlimb grip strength due to subcutaneous injections [30]. Combined exposure to xenobiotics including other organophosphates in long term low dose regiments reflecting the real life risk simulation showed no effect on muscle coordination alongside an increase in locomotor activity of treated rats [31].…”

Section: Discussionmentioning

confidence: 99%

Impacts of prolonged chlorpyrifos exposure on locomotion and slow-and fast- twitch skeletal muscles contractility in rats

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Impacts of prolonged chlorpyrifos exposure on locomotion and slow-and fast- twitch skeletal muscles contractility in rats

et al. 2019

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“…Because of the large doses used and the necessity for frank cholinergic toxicity to be present on repeated occasions, these results have little relevance to potential concerns for low-dose exposures to chlorpyrifos in the diet, but could be relevant to high-dose exposures that give rise to serious cholinergic toxicity, such as intentional exposures (suicide attempts) or occupational accidents. Numerous other studies have also failed to find persistent cognitive dysfunction (e.g., effects that persist after recovery from cholinesterase inhibition) following single or repeated exposures to chlorpyrifos at doses that inhibit brain AChE, although neurological and behavioral effects were clearly evident during periods of significant inhibition of brain AChE (Bushnell et al, 1993;1994;Cohn and MacPhail, 1997;Mattsson et al, 1996;Maurissen et al, 2000;Terry et al, 2003).…”

Section: Ivb2 Peripheral Neuropathy With or Without Intermediatementioning

confidence: 99%

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

Eaton¹,

Daroff²,

Autrup³

et al. 2008

Critical Reviews in Toxicology

555

394

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“…Acute neurotoxicity induced by carbaryl includes lowered activity levels, fasciculations, salivation, lacrimation with whole body tremors and dyspnea. Though the neurotoxicities of individual pesticide, either chlorpyrifos or carbaryl, have been well established (Mattsson et al,; Cañadas et al,), and there have been some in vitro (Tang et al,) and in vivo studies (Gordon et al,) of interactions between organophosphorus and carbamate pesticides, much less has been done concerning their subchronic neurotoxicological effects, especially with combined exposures.…”

Section: Introductionmentioning

confidence: 99%

Subchronic neurotoxicity of chlorpyrifos, carbaryl, and their combination in rats

Wang

Liang

Sun

et al. 2013

Environmental Toxicology

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Anticholinesterase pesticides have been widely used in agricultural and domestic settings and can be detected in the environment after long-term use. Although the acute toxic effects of chlorpyrifos and carbaryl have been well described, little is known about the chronic toxicity of the pesticides mixture. To investigate their chronic neurotoxicity, Wistar rats were exposed to chlorpyrifos, carbaryl, and their mixture (MIX) for 90 consecutive days. The activities of serum cholinesterase (ChE) as well as acetylcholinesterase (AChE) and neuropathy target esterase (NTE) in nerve tissues were determined. Furthermore, the histopathological examination was carried out. The results showed that ChE activity significantly decreased in all treated rats except the rats treated with low dose carbaryl. Treatment with middle- and high-dose chlorpyrifos and MIX in rats significantly inhibited AChE activity in the central nervous tissues, whereas treatment with carbaryl alone did not. In sciatic nerve, AChE activity was significantly inhibited by high-dose carbaryl and MIX, but not by chlorpyrifos alone. No significant NTE inhibition was observed in all treatment groups. Histopathological examination revealed that both chlorpyrifos and MIX treatment induced hippocampal damage. However, no obvious hippocampal damage was found in carbaryl-treated rats. Carbaryl and MIX, but not chlorpyrifos alone, induced pathological damage of sciatic nerve. Taken together, all of the results indicated that chlorpyrifos and carbaryl have different toxicological target tissues in nervous system and showed corresponding effects in the nervous tissues, which may reflect the different sensitivity of central and peripheral nervous tissues to different pesticides individually and in combination.

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Single-dose and 13-week repeated-dose neurotoxicity screening studies of chlorpyrifos insecticide

Cited by 36 publications

References 19 publications

Impacts of prolonged chlorpyrifos exposure on locomotion and slow-and fast- twitch skeletal muscles contractility in rats

Impacts of prolonged chlorpyrifos exposure on locomotion and slow-and fast- twitch skeletal muscles contractility in rats

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

Subchronic neurotoxicity of chlorpyrifos, carbaryl, and their combination in rats

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