Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)
David J Vance,
Saiful Basir,
Carol Lyn Piazza
et al.
Abstract:Camelid-derived, single-domain antibodies (VHHs) have proven to be extremely powerful tools in defining the antigenic landscape of immunologically heterogeneous surface proteins. In this report, we generated a phage-displayed VHH library directed against the candidate Lyme disease vaccine antigen, Outer surface protein A (OspA). Two alpacas were immunized with recombinant OspA serotype 1 (ST1) from Borrelia burgdorferi sensu stricto strain B31, in combination with the canine vaccine RECOMBITEK®Lyme containing … Show more
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