Single-Crystal to Single-Crystal Transformation of Metal–Organic Framework Nanoparticles for Encapsulation and pH-Stimulated Release of Camptothecin

Abstract

The phenomenon of single-crystal to single-crystal transformation and the performance change along with the transformation have been widely discovered, whereas the efficient utilization of the crystal transformation process is less reported. Herein, we present an interesting thermally driven single-crystal to single-crystal transformation of HNU-43. During transformation, the effective encapsulation of camptothecin (CPT) has been achieved as CPT-HNU-43 converts into CPT-HNU-43­(T), which cannot directly encapsulate CPT owing to the small channel size of HNU-43­(T). Following the successful packaging, the CPT can be triggered to gradually release as pH = 6.0 which is quite close to the acid environment of cancer cells. Furthermore, CPT-HNU-43­(T) nanoparticles show excellent biocompatibility, and the cancer cells can be effectively inhibited through the release of CPT.

Temperature- and solvent-induced reversible single-crystal-to-single-crystal transformations of TbIII-based MOFs with excellent stabilities and fluorescence sensing properties toward drug molecules

“…10 Single-crystal-tosingle-crystal (SCSC) conversion is an effective way to reconstruct the structures of MOFs 11 accompanied by the changes of coordination bonds, dimensions and porosity. [12][13][14][15] Interestingly, SCSC conversion can improve the stability 16,17 and luminescence performance 18 of MOFs. Luminescent metal-organic frameworks (LMOFs) have been proven to be one of the most promising luminescence sensing materials because of the expected luminescence features.…”

Desolvation-Degree-Induced Structural Dynamics in a Rigid Cerium–Organic Framework Exhibiting Tandem Purification of Ethylene from Acetylene and Ethane

“…On the other hand, dynamic MOFs have gained great attention recently, thanks to their intriguing structural dynamics in a manner of single-crystal to single-crystal transformation under external stimuli (e.g., pressure, temperature, light, and guest molecules) and diverse applications ranging from gas adsorption/separation to molecular sensing, drug release, etc. − Among them, a few flexible MOFs have revealed fascinating separation behaviors for C 2 H 2 /C 2 H 4 and C 2 H 6 /C 2 H 4 gas mixtures based on gate-opening effects. − In contrast, the host frameworks of most rigid MOFs seem invariable under external stimuli and the reported dynamic ones mostly focused on the elucidation of sophisticated structural transformations and preliminary sorption characterizations. ,, No reports have been made pertinent to ethylene purification.…”

ZIF-L to ZIF-8 Transformation: Morphology and Structure Controls

“…Numerous investigations have attempted to regulate the morphology of MOFs by tuning the synthesis condition. (e.g., However, there is no technique that can be broadly applied to metal-organic frameworks, and there is a fundamental lack of understanding of inclusion of additives [ 3 ], pH control [ 16 ], and synthesis solvent control [ 17 ]). how to stimulate the formation of crystals with a target shape.…”