Single cross‐sectional area of pectoralis muscle by computed tomography – correlation with bioelectrical impedance based skeletal muscle mass in healthy subjects

Kim, Young Saing; Kim, Eun Young; Kang, Shin Myung; Ahn, Hee Kyung; Kim, Hyung Sik

doi:10.1111/cpf.12333

Cited by 34 publications

(28 citation statements)

References 24 publications

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“…Muscle CSA was independently associated with 6MWD, strength training volumes, and post‐transplant hospital length of stay. This technique of measuring muscle CSA provides a valid surrogate for muscle mass with no added cost or radiation exposure.…”

Section: Discussionmentioning

confidence: 99%

Thoracic muscle cross-sectional area is associated with hospital length of stay post lung transplantation: a retrospective cohort study

et al. 2017

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Low muscle mass is common in lung transplant (LTx) candidates; however, the clinical implications have not been well described. The study aims were to compare skeletal muscle mass in LTx candidates with controls using thoracic muscle cross-sectional area (CSA) from computed tomography and assess the association with pre- and post-transplant clinical outcomes. This was a retrospective, single-center cohort study of 527 LTx candidates [median age: 55 IQR (42-62) years; 54% male]. Thoracic muscle CSA was compared to an age- and sex-matched control group. Associations between muscle CSA and pre-transplant six-minute walk distance (6MWD), health-related quality of life (HRQL), delisting/mortality, and post-transplant hospital outcomes and one-year mortality were evaluated using multivariable regression analysis. Muscle CSA for LTx candidates was about 10% lower than controls (n = 38). Muscle CSA was associated with pre-transplant 6MWD, but not HRQL, delisting or pre- or post-transplant mortality. Muscle CSA (per 10 cm difference) was associated with shorter hospital stay [0.7 median days 95% CI (0.2-1.3)], independent of 6MWD. In conclusion, thoracic muscle CSA is a simple, readily available estimate of skeletal muscle mass predictive of hospital length of stay, but further study is needed to evaluate the relative contribution of muscle mass versus functional deficits in LTx candidates.

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Section: Discussionmentioning

confidence: 99%

Thoracic muscle cross-sectional area is associated with hospital length of stay post lung transplantation: a retrospective cohort study

et al. 2017

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“…In fact, numerous studies have used L3-SMI to determine sarcopenia [ 24 , 26 – 28 , 33 – 36 ]. However, a recent study reported that the cross-sectional area of the pectoralis muscle determined by low-dose chest CT scan was significantly correlated with total body skeletal muscle mass, as measured by bioelectrical impedance analysis in healthy subjects [ 37 ]. The clinical importance of sarcopenia determined by the pectoralis muscle was assessed in respiratory tract disorders such as chronic obstructive pulmonary disease (COPD) [ 38 ] and small cell lung cancer (SCLC) [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Taken together with these previous reports, the present study more strongly supports our previous finding [ 29 ] that sarcopenia determined by PM-SMI has an adverse impact in patients with DLBCL. There is another advantage in using the pectoralis muscle to determine sarcopenia in that it can be easily measured due to its anatomical simplicity [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

A comparison of pectoralis versus lumbar skeletal muscle indices for defining sarcopenia in diffuse large B-cell lymphoma - two are better than one

Park

Song

et al. 2017

Oncotarget

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BackgroundsSarcopenia is known to be associated with poor clinical outcome in patients with diffuse large B-cell lymphoma (DLBCL). There is no consensus concerning the optimal method to define sarcopenia in DLBCL.MethodsWe retrospectively reviewed 193 DLBCL patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy. Sarcopenia was classified by the region where the pretreatment skeletal muscle index (SMI) was measured.ResultsBoth the sarcopenia-L3 and sarcopenia-pectoralis muscle (PM) groups had increased incidences of severe treatment-related toxicities and treatment discontinuation compared with the non-sarcopenia-L3 and non-sarcopenia-PM groups, respectively. The sarcopenia-L3 and non-sarcopenia-L3 groups had 5-year overall survival (OS) rates of 40.5% and 67.8% (p < 0.001), respectively. The sarcopenia-PM and non-sarcopenia-PM groups had 5-year OS rates of 35.9% and 69.0% (p < 0.001), respectively. When the sarcopenia-L3 alone and sarcopenia-PM alone groups were compared, there were no differences in baseline characteristics, treatment toxicity, or survival. In multivariate analysis, when compared with the non-sarcopenia-both group, OS was significantly worse in the sarcopenia-both group (HR, 2.480; 95% CI, 1.284 – 4.792; p = 0.007), but not in patients with either sarcopenia-L3 alone or sarcopenia-PM alone (p = 0.151).ConclusionsL3- and PM-SMIs are equally useful to define sarcopenia, which is related to intolerance to R-CHOP therapy and to worse survival in patients with DLBCL. More prognostic information can be obtained when these two SMIs are combined to define sarcopenia.

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“…Pectoralis muscle has the merit of being easily demarcated and quantified due to its anatomical features on chest CT images, and furthermore, prognosis was poor in male SCLC patients with a low PMA and an elevated neutrophil-to-lymphocyte ratio [11]. In a recent study [15], a moderate correlation (r = 0.665, p < 0.001) was observed between CT-determined PMA and BIA-determined total body SMM in healthy subjects, and this association remained significant after adjusting for sex, weight, height, and age. Further large-scale study is warranted to evaluate the usefulness of PMA for quantifying SMM and for predicting prognosis in oncologic patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of sarcopenia in small-cell lung cancer patients by routine chest CT

Kim

Park

et al. 2016

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Single cross‐sectional area of pectoralis muscle by computed tomography – correlation with bioelectrical impedance based skeletal muscle mass in healthy subjects

Abstract: Cross-sectional area of the pectoralis muscles on single axial CT images shows moderate correlation with total body SMM determined by BIA in healthy subjects.

Cited by 34 publications

References 24 publications

Thoracic muscle cross-sectional area is associated with hospital length of stay post lung transplantation: a retrospective cohort study

Thoracic muscle cross-sectional area is associated with hospital length of stay post lung transplantation: a retrospective cohort study

A comparison of pectoralis versus lumbar skeletal muscle indices for defining sarcopenia in diffuse large B-cell lymphoma - two are better than one

Evaluation of sarcopenia in small-cell lung cancer patients by routine chest CT

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