Single‐Column‐Based Heck Coupling, Condensation and Alkylation Strategy: Synthesis of 2‐Benzoyl‐2‐alkyl‐2,3‐dihydro‐1H‐inden‐1‐ones

Abstract

An efficient method for the synthesis of alkyl benzoyl indanones via a simple intermolecular Heck coupling followed by intramolecular condensation, and alkylation is presented. Notably, the strategy exhibited good substrate scope and enabled the synthesis of diverse alkyl substituted 1,3‐dicarbonyl products. Significantly, this protocol was successful using a single‐column purification technique.