Single chain polymeric nanoparticles as compartmentalised sensors for metal ions

Gillissen, Martijn A. J.; Voets, Ilja K.; Meijer, E. W.; Palmans, Anja R. A.

doi:10.1039/c2py20350b

Cited by 138 publications

(134 citation statements)

References 65 publications

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“…[5][6][7] Inspired by this model of biopolymers, folding a single linear polymer chain into a single chain nanoparticle (SCNP) has been recognized as a robust strategy for the construction of biopolymeric nanoparticles with potential applications in catalysis, sensing or biotechnology. [8][9][10][11][12][13][14] Although the design and synthesis of single chain objects has recently received great attention, 15 the development in this field is still in its initial phase. So far, several types of strategies to mediate the single chain collapse to form SCNPs have been explored, [16][17][18][19][20][21][22] ranging from hydrogen bonding, 23-27, 10, 28-31 covalent bonding, [32][33][34][35][36] to dynamic covalent bonding.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Sequence-Controlled Multiblock Single Chain Nanoparticles by a Stepwise Folding–Chain Extension–Folding Process

et al. 2016

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Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. Publisher's statement:"This document is the Accepted Manuscript version of a Published Work that appeared in final form in Macromolecules copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work http://pubs.acs.org/page/policy/articlesonrequest/index.html ." A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP URL above for details on accessing the published version and note that access may require a subscription. ABSTRACTThe specific activity of proteins can be traced back to their highly defined tertiary structure, which is a result of a perfectly controlled intra-chain folding process. In the herein presented work the folding of different distinct domains within a single macromolecule is demonstrated. RAFT polymerization was used to produce multi-block copolymers, which are decorated with pendant hydroxyl groups in foldable sections, separated by non-functional spacer blocks in between. OH-bearing blocks were folded using an isocyanate cross linker prior to chain extension to form single chain nanoparticles (SCNP). After addition of a spacer block and a further OH decorated block, folding was repeated to generate individual SCNP within a polymer chain. Control experiments were performed indicating the absence of inter block cross linking. SCNP were found to be condensed by a combination of covalent and supra molecular (hydrogen bonds) linkage. The approach was used to create a highly complex penta-block copolymer having three individually folded subdomains with an overall dispersity of 1.21. The successful formation of SCNP was confirmed by size exclusion chromatography (SEC), nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC) and atomic force microscopy (AFM).

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Section: Introductionmentioning

confidence: 99%

Synthesis of Sequence-Controlled Multiblock Single Chain Nanoparticles by a Stepwise Folding–Chain Extension–Folding Process

et al. 2016

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“…I agree with the suggested changes, that can be made easily by the editorial office. [7,22,28,29], poly(styrene) [3,22,23,[30][31][32], poly(haloalkyl styrene) [3,33], poly(4-N-Boc-vinylaniline) [33], poly(sodium 4-styrenesulfonate) [22], poly(N-alkyl acrylamide) [22,34,35] Atom transfer radical polymerization ATRP Poly(alkyl methacrylates) [14], poly(alkyl acrylates) [11,12], poly(styrene) [36], poly(N-hydroxyethyl acrylamide) [37] Nitroxide mediated radical polymerization NMP Poly(alkyl methacrylates) [9,[38][39][40], poly(alkyl acrylates) [40], poly(styrene) [2,38,40], poly(haloalkyl styrene) [40], poly(fluorene) [41] Ring opening metathesis polymerization ROMP Poly(-caprolactone) [38], poly(carbonates) [42] poly(norbornenes) [13,43,44] * For SCNP copolymer and terpolymer precursors, only the nature of the main component is indicated.…”

Section: Controlled Polymerizationmentioning

confidence: 99%

“…This is a consequence of the polydisperse nature (in size and composition) of current synthetic polymers showing a distribution of molar mass when compared to the perfectly monodisperse nature and precise chemical sequence of natural biomacromolecules. Even so, due to their exceptional properties, unimolecular polymeric nanoparticles have been evaluated as rheology agents [2,3], enzyme mimics [4,5], drug/siRNA/peptide nanocarriers [6][7][8][9], image contrast agents [3,[10][11][12], sensors [13], catalytic systems in water [14], and smart gels [15]. As illustrated in Figure 1, synthesis of single-chain nanoparticles relies on the use of a combination of three main different techniques [3].…”

Section: Introductionmentioning

confidence: 99%

Advances in Click Chemistry for Single-Chain Nanoparticle Construction

2013

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Single-chain polymeric nanoparticles are artificial folded soft nano-objects of ultra-small size which have recently gained prominence in nanoscience and nanotechnology due to their exceptional and sometimes unique properties. This review focuses on the current state of the investigations of click chemistry techniques for highly-efficient single-chain nanoparticle construction. Additionally, recent progress achieved for the use of well-defined single-chain nanoparticles in some promising fields, such as nanomedicine and catalysis, is highlighted.

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“…They are synthesized, generally at high dilution (∼ 1 mg/mL), through purely intramolecular cross-linking of the reactive functional groups of single polymer precursors. A growing interest is being devoted in recent years to develop a SCNPbased technology with multiple applications in catalysis [6][7][8][9] , nanomedicine 10,11 , bioimaging 12,13 , biosensing 14 , or rheology [15][16][17] among others. A recent review of the state-of-the-art in fundamentals and applications of SCNPs can be found in Ref.…”

Section: Introductionmentioning

confidence: 99%

Effects of precursor topology and synthesis under crowding conditions on the structure of single-chain polymer nanoparticles

Formanek

Moreno

2017

Soft Matter

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By means of molecular dynamics simulations we investigate the formation of single-chain nanoparticles through intramolecular cross-linking of polymer chains, in the presence of their precursors acting as purely steric crowders in concentrated solution. In the case of the linear precursors, the structure of the resulting SCNPs is weakly affected by the density at which the synthesis is performed. Crowding has significant effects if ring precursors are used: higher concentrations lead to the formation of SCNPs with more compact and spherical morphologies. Such SCNPs retain in the swollen state (high dilution) the crumpled globular conformations adopted by the ring precursors in the crowded solutions. Increasing the concentration of both the linear and ring precursors up to 30 % leads to faster formation of the respective SCNPs.

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Single chain polymeric nanoparticles as compartmentalised sensors for metal ions

Cited by 138 publications

References 65 publications

Synthesis of Sequence-Controlled Multiblock Single Chain Nanoparticles by a Stepwise Folding–Chain Extension–Folding Process

Synthesis of Sequence-Controlled Multiblock Single Chain Nanoparticles by a Stepwise Folding–Chain Extension–Folding Process

Advances in Click Chemistry for Single-Chain Nanoparticle Construction

Effects of precursor topology and synthesis under crowding conditions on the structure of single-chain polymer nanoparticles

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