Single‐Chain Polymer Self‐Assembly Using Complementary Hydrogen Bonding Units

Abstract

A triblock copolymer containing the complementary hydrogen bonding recognition pair ureidoguanosine-diaminonaphthyridine (UG-DAN) as pendant functional groups is synthesized using ring-opening metathesis polymerization (ROMP). The norbornene-based DAN monomer is shown to allow for a controlled polymerization when polymerized in the presence of a modified-UG molecule that serves as a protecting group, subsequently allowing for the fabrication of functionalized triblock copolymers. The self-assembly of the copolymers was characterized using dynamic light scattering and (1) H NMR spectroscopy. It is demonstrated that the polymers self-assemble via complementary hydrogen bonding motifs even at low dilutions, indicating intramolecular interactions.

Single‐Chain Folding of Synthetic Polymers: A Critical Update

“…The concept of forming SCNPs via the repeat unit folding approach using complementary hydrogen-bonding interactions of ureidoguanosine (UG) and diaminonaphthyridine (DAN) was further explored by Weck and colleagues. [ 78 ] Intramolecular self-assembly of an ABC-type triblock copolymer using orthogonal hydrogen-bonding motifs as side-chain recognition units was studied, where the A and C blocks contained protected UG and DAN pendant functional groups, respectively. DLS and 1 H NMR spectroscopy showed that the linear triblock copolymer chains folded into SCNPs at high dilution via intramolecular UG-DAN hydrogen-bonding interactions.…”

Supramolecular Nanoparticles via Single-Chain Folding Driven by Ferrous Ions

“…Hawker and co-workers reported self-complementary hydrogen bonding units to prepare supramolecular single-chain nanoparticles. [ 28 ] Later, hydrogen bonding interaction, [ 9,29,[31][32][33][34] host-guest interaction, [ 30,35 ] hydrophobic interaction, [ 8,36,37 ] and metal coordination interaction [38][39][40] have also been exploited to achieve intramolecular collapsing. With interest growing in fabricating single-chain nanoparticles via noncovalent interaction, an easy and effi cient synthetic method is needed to achieve intramolecular collapsing.The metal coordination interaction is a useful method to prepare supramolecular nanoparticles.…”

RAFT dispersion polymerization: a method to tune the morphology of thymine-containing self-assemblies

“…29 Inspired by the previous study, 66 an adenine-containing mediator was used in this work to investigate its effect on the resultant self-assembly morphologies and as well as the dispersity of the resultant copolymers. The adeninecontaining mediator, 9-hexyladenine (Scheme 2) was synthesized according to a previous literature report (Scheme S1 and Figure S25).…”