Single-center investigation on central-line–associated bloodstream infections and blood-culture contamination during the early months of the coronavirus disease 2019 (COVID-19) pandemic

Abstract

In this retrospective cohort study, we assessed central-line–associated bloodstream infections (CLABSIs) and blood-culture contamination frequency during the first pandemic wave. Coronavirus disease 2019 (COVID-19) was significantly associated with CLABSI and blood-culture contamination. In the COVID-19 cohort, malignancy was associated with CLABSI. Black race, end-stage renal disease, and obesity were associated with blood-culture contamination.

Coronavirus disease 2019 (COVID-19) impact on central-line-associated bloodstream infections (CLABSI): a systematic review

“…0005), agency hours ( P <0.01), and percent of premium pay that were agency hours ( P <0.0001), confirming again higher numbers of travelling staff and overstretched healthcare workers during the pandemic [ 20 ]. The study from Texas also confirmed a similar association between COVID-19 and an increase in CLABSI rates [ 21 ]. The authors also noted an increase in the blood culture contamination rate.…”

“…, 2022 [ 31 ] COVID-19 HAI, including CLABSI, CAUTI and VAE India, Mongolia, Jordan, Lebanon, Palestine, Egypt, Turkey Retrospective data analysis International Nosocomial Infection Control Consortium (INICC) Surveillance Online System (ICUs in 7 low- and middle-income countries, LMICs, for a total of 7,775 patients) Increase in CLABSI rates (2.54 versus 4.73 per 1000 central line days) when comparing 2019 (non-COVID) versus 2020 (COVID) Increase Wang et al. , 2022 [ 21 ] COVID-19 CLABSI and blood-culture contamination rate USA Retrospective cohort study University of Texas Medical Branch (UTMB) health system COVID-19 was associated with significant increase in blood culture contamination and CLABSI rates Increase Black race, end-stage renal disease and obesity as significant risk factors Weiner-Lastinger et al. , 2022 [ 58 ] COVID-19 HAIs, including CLABSI, CAUTI, CDI and MRSA infections USA Retrospective daa analysis National Healthcare Safety Network (NHSN) database (nearly all US hospitals) Significant increase in the state-level standardized infection ratios (SIRs) for CLABSI observed in 2020 Increase …”

“…Various other studies from Illinois [ 20 ], Texas [ 21 ], California [ 22 , 23 ] and the Veteran Affairs (VA) system [ 24 , 25 ] also showed a significant increase in CLABSI rates during the pandemic. The data from Illinois not only highlighted a significant increase in CLABSI per 1000 patient days but also a wider increase in the total number of infections per 1000 patient days ( P< 0 .…”

“…In addition, most of the papers only reported the data without providing additional evidence to explain such increase. Only few studies have successfully demonstrated a link with acute and community hospitals, lack of IPC audits, increased workload and use of temporary agency staff [ [19] , [20] , [21] , 36 ].…”