Single-cell Transcriptomics Reveals Activation of Macrophages in All-trans Retinoic Acid (atRA)-induced Cleft Palate
Binqing Wang,
Meng Xu,
Jingjing Zhao
et al.
Abstract:Cleft palate is among the most common birth defects with an impact on swallowing and speaking and is difficult to diagnose with ultrasound during pregnancy. In this study, we systematically capture the cellular composition of all-trans retinoic acid (atRA)-exposed and normal embryonic gestation 16.5 days mouse palate by the single-cell RNA sequencing technique. The authors identified 14 major cell types with the largest proportion of fibroblasts. The proportion of myeloid cells in atRA-exposed palate was marke… Show more
“… 82 The recent single-cell RNA-seq and single-cell multiome studies in mice also showed that Fos and Jun were involved in secondary palate development 54 and all- trans retinoic-acid-induced CP. 83 …”
“… 82 The recent single-cell RNA-seq and single-cell multiome studies in mice also showed that Fos and Jun were involved in secondary palate development 54 and all- trans retinoic-acid-induced CP. 83 …”
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