Single-cell Transcriptomics of Postimplantation Embryos: Unveiling Aneuploidy Effects and Lineage Dynamics
Sheila Yat Sze Kwok,
Lilach Marom Haham,
Stewart Russell
et al.
Abstract:Transfer of aneuploid human embryos, as defined by the presence of > 80% cells with an abnormal chromosome complement, is clinically associated with pregnancy loss or congenital abnormalities. However, the transfer of diploid-aneuploid mosaic embryos can lead to healthy live births, indicating the early presence of aneuploid cells might not necessarily compromise embryo developmental competence. Currently, a comprehensive investigation of the molecular mechanisms determining post-implantation aneuploid cell… Show more
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