Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human
Junxian He,
Jindong Li,
Yanqing Li
et al.
Abstract:The male reproductive system experiences degradation with age, predominantly impacting the testes. Testicular aging can result in failure to produce physiological testosterone levels, normal sperm concentrations, or both. However, we cannot predict the onset of testicular aging in advance. Using single-cell RNA sequencing (scRNA-seq) from Gene Expression Omnibus (GEO) database, we conducted cell-cell communication network of human testis between older and young group, indicating Leydig cells’ potential role in… Show more
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