Single-cell transcriptome and T cell receptor profiling of the tuberculin skin test
Carolin T. Turner,
Joshua Rosenheim,
Clare Thakker
et al.
Abstract:The tuberculin skin test (TST) is a cutaneous delayed hypersensitivity reaction to antigen fromMycobacterium tuberculosis(Mtb). We provide the first single cell sequencing characterisation of the human TST reaction, based on skin suction blisters induced at the site of the TST on day 2 in 31 individuals. Integrated single cell RNA and TCR sequencing showed the immune response to be dominated by T cells, with smaller populations of NK cells and myeloid cells. T cells comprised CD4, CD8, gamma/delta and NK T cel… Show more
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