Abstract:Kidneys of healthy individuals filter 4 to 25 g of fructose (FRU) a day, equivalent to ~10% of the filtered glucose. FRU reabsorbed by proximal tubules (PTs) is mostly used in gluconeogenesis. Elevated dietary FRU alters hormonal signaling in PTs and increases oxidative stress, which overtime, leads to salt-sensitive hypertension, tubulointerstitial injury, and glomerular damage. Four apical transporters could transport FRU at physiological concentrations: SGLT5 (km0.62 mM), NAGLT1 (km4.5 mM), GLUT5 (km12.6 mM… Show more
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