Single-cell transcriptional landscape of temporal neutrophil response to burn wound in larval zebrafish
Yiran Hou,
Parth Khatri,
Julie Rindy
et al.
Abstract:Neutrophils accumulate early in tissue injury. However, the cellular and functional heterogeneity of neutrophils during homeostasis and in response to tissue damage remains unclear. Here, we use larval zebrafish to understand neutrophil responses to thermal injury. Single-cell transcriptional mapping of myeloid cells during a 3-day time course in burn and control larvae revealed distinct neutrophil subsets and their cell-cell interactions with macrophages across time and conditions. The trajectory formed by th… Show more
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