Single-cell transcription mapping of murine and human mammary organoids responses to female hormones
Jenelys Ruiz Ortiz,
Steven M. Lewis,
Michael F. Ciccone
et al.
Abstract:During female adolescence and pregnancy, rising levels of hormones result in a cyclic source of signals that control the development of mammary tissue. While such alterations are well understood from a whole-gland perspective, the alterations that such hormones bring to organoid cultures derived from mammary glands have yet to be fully mapped. This is of special importance given that organoids are considered suitable systems to understand cross species breast development. Here we utilized single-cell transcrip… Show more
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