Single cell suppression profiling of human regulatory T cells
Jonas Søndergaard,
Janyerkye Tulyeu,
David Priest
et al.
Abstract:Regulatory T cells (Tregs) play an important role in regulating immune homeostasis in health and disease. Traditionally their suppressive function has been assayed by mixing purified cell populations, which does not provide an accurate picture of a physiologically relevant immune response. To overcome this limitation, we here developed “single cell suppression profiling of human Tregs” (scSPOT). scSPOT is more informative and physiological than traditional assays, using a 52-marker CyTOF panel, a cell division… Show more
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