2017
DOI: 10.1038/nature24280
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Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites

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Cited by 206 publications
(341 citation statements)
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“…Comparative analysis of our single-cell data with those from Poran et al 15 and the bulk RNA-seq dataset validated the results by revealing a significant overlap in genes with commitment-associated expression profiles, despite differences in experimental setup and sequencing pipelines ( Table 2 and Supplementary File 5). Poran et al 15 also observed an enrichment of AP2-G binding motifs upstream of commitment-associated genes.…”
Section: Resultssupporting
confidence: 74%
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“…Comparative analysis of our single-cell data with those from Poran et al 15 and the bulk RNA-seq dataset validated the results by revealing a significant overlap in genes with commitment-associated expression profiles, despite differences in experimental setup and sequencing pipelines ( Table 2 and Supplementary File 5). Poran et al 15 also observed an enrichment of AP2-G binding motifs upstream of commitment-associated genes.…”
Section: Resultssupporting
confidence: 74%
“…This hypothesis is also reinforced by the recent scRNA-seq study 15 , and by previous work using plaque assays and progeny analysis with gametocyte-specific antibodies 10 . To validate these observations directly, we investigated sexual commitment in reporter parasites.…”
Section: Resultsmentioning
confidence: 74%
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