Abstract:Background: Modelling atopic dermatitis (AD) in vitro is
paramount to understand the disease pathophysiology and identify novel
treatments. Previous studies have shown that the Th2 cytokines IL-4 and
IL-13 induce AD-like features in keratinocytes in vitro. However,
it has not been systematically researched whether the addition of Th2
cells, their supernatants or a 3D structure are superior to model AD
compared to simple 2D cell culture with cytokines. Methods: For
the first time, we investigated what in vitro … Show more
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