Abstract:Congenital syphilis is a vertically transmitted bacterial infection caused by
Treponema pallidum
, often causing multidomain neurodevelopmental disabilities. However, little is known about the pathogenesis of this disease. Brain organoids platform derived from the induced pluripotent stem cell (iPSC) is exposed to
T. pallidum
infection for modelling congenital neurodevelopmental impairment. Single-cell RNA sequencing is used for identifying the subpopulations of differentially expressed genes and cellular h… Show more
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