Single‐cell profiling reveals the metastasis‐associated immune signature of hepatocellular carcinoma
Deyuan Zhong,
Ying Shi,
Wenzhe Ma
et al.
Abstract:AimMetastasis is the leading cause of mortality in hepatocellular carcinoma (HCC). The metastasis‐associated immune signature in HCC is worth exploring.MethodsBioinformatic analysis was conducted based on the single‐cell transcriptome data derived from HCC patients in different stages. Cellular composition, pseudotime state transition, and cell–cell interaction were further analyzed and verified.ResultsGenerally, HCC with metastasis exhibited suppressive immune microenvironment, while HCC without metastasis ex… Show more
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