Single-cell profiling of penta- and tetradactyl mouse limb buds identifies mesenchymal progenitors controlling digit numbers and identities
Victorio Palacio,
Anna Pancho,
Angela Morabito
et al.
Abstract:SUMMARYThe cellular mechanisms controlling digit numbers and identities have remained elusive. Profiling of wild-type (pentadactyl) andGrem1tetradactyl mouse limb buds identifies cellular changes affecting two limb bud mesenchymal progenitor (LMP) populations. In mutant limb buds, the anteriorly biased distribution of peripheral LMPs (pLMPs) is lost and the population expanded, while the distal-posterior LMP (dLMP) population is reduced from early stages onward. Analysis of LMP signature genes in wildtype and … Show more
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