Single-cell phylodynamic inference of tissue development and tumor evolution with scPhyloX
Kun Wang,
Zhaolian Lu,
Zeqi Yao
et al.
Abstract:Phylodynamics inference (PI) is a powerful approach for quantifying population dynamics and evolutionary trajectories of natural species based on phylogenetic trees. The emergence of single-cell lineage tracing technologies now enables the reconstruction of phylogenetic trees for thousands of individual cells within a multicellular organism, opening avenues for employing PI methodologies at the cellular level. However, the intricate process of cell differentiation poses challenges for directly applying current… Show more
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