Single cell ‘omic profiles of human aortic endothelial cellsin vitroand human atherosclerotic lesionsex vivoreveals heterogeneity of endothelial subtype and response to activating perturbations
Abstract:Objective: Endothelial cells (ECs) regulate atherogenesis with Endothelial-to-Mesenchymal (EndMT) transition correlating with disease. Single cell (sc) effects of EndMT perturbations in vitro, with quantitative comparison to signatures of human lesions in vivo is lacking. Approach and Results: Multiomic profiling that concurrently measures sc RNA and ATAC was performed on 8 distinct primary cultures of human aortic ECs exposed to 7-day of EndMT-promoting perturbations: IL1B, TGFB2, and ERG knockdown (siERG). M… Show more
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