Single-cell multi-omics analysis reveals cooperative transcription factors for gene regulation in oligodendrocytes
Jerome J. Choi,
John Svaren,
Daifeng Wang
Abstract:Oligodendrocytes are the myelinating cells within the central nervous system. Many oligodendrocyte genes have been associated with brain disorders. However, how transcription factors (TFs) cooperate for gene regulation in oligodendrocytes remains largely uncharacterized. To address this, we integrated scRNA-seq and scATAC-seq data to identify the cooperative TFs that co-regulate the target gene (TG) expression in oligodendrocytes. First, we identified co- binding TF pairs whose binding sites overlapped in olig… Show more
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